Your browser doesn't support javascript.
loading
Increased SOX2 expression in salivary gland carcinoma ex pleomorphic adenoma progression: an association with adverse outcome.
Sedassari, Bruno Tavares; Rodrigues, Maria Fernanda Setúbal Destro; Conceição, Thalita Santana; Mariano, Fernanda Viviane; Alves, Venâncio Avancini Ferreira; Nunes, Fábio Daumas; Altemani, Albina; de Sousa, Suzana Cantanhede Orsini Machado.
Afiliación
  • Sedassari BT; Department of Oral and Maxillofacial Pathology, School of Dentistry, University of São Paulo, Av. Professor Lineu Prestes, São Paulo, São Paulo, 222705208-000, Brazil. brunosedassari@usp.br.
  • Rodrigues MFSD; Department of Oral and Maxillofacial Pathology, School of Dentistry, University of São Paulo, Av. Professor Lineu Prestes, São Paulo, São Paulo, 222705208-000, Brazil.
  • Conceição TS; Department of Oral and Maxillofacial Pathology, School of Dentistry, University of São Paulo, Av. Professor Lineu Prestes, São Paulo, São Paulo, 222705208-000, Brazil.
  • Mariano FV; Department of Anatomic Pathology, School of Medicine, State University of Campinas, R. Tessália Vieira de Camargo, 126, Campinas, São Paulo, 13084-971, Brazil.
  • Alves VAF; Department of Anatomic Pathology, School of Medicine, University of São Paulo, Av. Dr. Arnaldo, São Paulo, São Paulo, 45501246-903, Brazil.
  • Nunes FD; Department of Oral and Maxillofacial Pathology, School of Dentistry, University of São Paulo, Av. Professor Lineu Prestes, São Paulo, São Paulo, 222705208-000, Brazil.
  • Altemani A; Department of Anatomic Pathology, School of Medicine, State University of Campinas, R. Tessália Vieira de Camargo, 126, Campinas, São Paulo, 13084-971, Brazil.
  • de Sousa SCOM; Department of Oral and Maxillofacial Pathology, School of Dentistry, University of São Paulo, Av. Professor Lineu Prestes, São Paulo, São Paulo, 222705208-000, Brazil.
Virchows Arch ; 471(6): 775-784, 2017 Dec.
Article en En | MEDLINE | ID: mdl-28842747
SOX2 is a regulatory factor of embryonic stem cells that has been implicated in carcinogenesis and cancer progression. We aimed to investigate the potential role of SOX2 in the stepwise progression from pleomorphic adenoma (PA) to invasive carcinoma ex pleomorphic adenoma (CXPA), evaluating its prognostic significance as well. Thirty PAs without malignant transformation and 25 CXPAs presenting both luminal or myoepithelial differentiation (7 intracapsular and 18 extracapsular) were evaluated immunohistochemically for SOX2 expression. Of these, 24 CXPAs (96%) were positive to SOX2, being 6 intracapsular carcinomas (85.7%) and all the 18 extracapsular carcinomas (100%). Residual PA areas and PA without malignant transformation were negative. High SOX2 expression levels (> 50% of positive cells) were correlated with high histological grade (p = 0.02), brisk mitotic activity (p = 0.01), advanced pT stage (p = 0.01), tumor recurrence (p = 0.01), and development of distant metastasis (p = 0.004). Still, overall survival rates were shorter in patients with extracapsular CXPA exhibiting diffuse SOX2 expression. These results suggest that SOX2 may play an important role in carcinogenesis and progression of CXPA and is also related with prognostic indicators in CXPAs with extracapsular invasion. Although direct therapeutic intervention in SOX2 may result in unwanted complications due to its constitutive functions, strategic approach to SOX2-related pathways may provide new therapeutic opportunities for patients with invasive CXPA.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de las Glándulas Salivales / Adenocarcinoma / Biomarcadores de Tumor / Adenoma Pleomórfico / Factores de Transcripción SOXB1 Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: Virchows Arch Asunto de la revista: BIOLOGIA MOLECULAR / PATOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de las Glándulas Salivales / Adenocarcinoma / Biomarcadores de Tumor / Adenoma Pleomórfico / Factores de Transcripción SOXB1 Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: Virchows Arch Asunto de la revista: BIOLOGIA MOLECULAR / PATOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Alemania