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Comparative effects of traditional Chinese and Western migraine medicines in an animal model of nociceptive trigeminovascular activation.
Zhao, Yonglie; Martins-Oliveira, Margarida; Akerman, Simon; Goadsby, Peter J.
Afiliación
  • Zhao Y; 1 Department of Neurology, University of California, San Francisco, CA, USA.
  • Martins-Oliveira M; 2 Basic and Clinical Neurosciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
  • Akerman S; 1 Department of Neurology, University of California, San Francisco, CA, USA.
  • Goadsby PJ; 1 Department of Neurology, University of California, San Francisco, CA, USA.
Cephalalgia ; 38(7): 1215-1224, 2018 06.
Article en En | MEDLINE | ID: mdl-28836816
Background Migraine is a highly prevalent and disabling disorder of the brain with limited therapeutic options, particularly for preventive treatment. There is a need to identify novel targets and test their potential efficacy in relevant preclinical migraine models. Traditional Chinese medicines have been used for millennia and may offer avenues for exploration. Methods We evaluated two traditional Chinese medicines, gastrodin and ligustrazine, and compared them to two Western approaches with propranolol and levetiracetam, one effective and one ineffective, in an established in vivo rodent model of nociceptive durovascular trigeminal activation. Results Intravenous gastrodin (30 and 100 mg/kg) significantly inhibited nociceptive dural-evoked neuronal firing in the trigeminocervical complex. Ligustrazine (10 mg/kg) and propranolol (3 mg/kg) also significantly inhibited dural-evoked trigeminocervical complex responses, although the timing of responses of ligustrazine does not match its pharmacokinetic profile. Levetiracetam had no effects on trigeminovascular responses. Conclusion Our data suggest gastrodin has potential as an anti-migraine treatment, whereas ligustrazine seems less promising. Interestingly, in line with clinical trial data, propranolol was effective and levetiracetam not. Exploration of the mechanisms and modelling effects of Chinese traditional therapies offers novel route for drug discovery in migraine.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nervio Trigémino / Manejo del Dolor / Medicina Tradicional China / Trastornos Migrañosos / Neuronas Aferentes Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Revista: Cephalalgia Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nervio Trigémino / Manejo del Dolor / Medicina Tradicional China / Trastornos Migrañosos / Neuronas Aferentes Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Revista: Cephalalgia Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido