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Copper(II)-bis(thiosemicarbazonato) complexes as anti-chlamydial agents.
Marsh, James W; Djoko, Karrera Y; McEwan, Alastair G; Huston, Wilhelmina M.
Afiliación
  • Marsh JW; The iThree Institute, University of Technology Sydney, 15 Broadway, Ultimo, NSW 2007, Australia.
  • Djoko KY; School of Chemistry and Molecular Biosciences and Australian Centre for Infectious Disease Research, The University of Queensland, St Lucia, QLD 4072, Australia.
  • McEwan AG; School of Chemistry and Molecular Biosciences and Australian Centre for Infectious Disease Research, The University of Queensland, St Lucia, QLD 4072, Australia.
  • Huston WM; School of Life Sciences, University of Technology Sydney, 15 Broadway, Ultimo, NSW 2007, Australia.
Pathog Dis ; 75(7)2017 09 29.
Article en En | MEDLINE | ID: mdl-28830076
Lipophilic copper (Cu)-containing complexes have shown promising antibacterial activity against a range of bacterial pathogens. To examine the susceptibility of the intracellular human pathogen Chlamydia trachomatis to copper complexes containing bis(thiosemicarbazone) ligands [Cu(btsc)], we tested the in vitro effect of CuII-diacetyl- and CuII-glyoxal-bis[N(4)-methylthiosemicarbazonato] (Cu(atsm) and Cu(gtsm), respectively) on C. trachomatis. Cu(atsm) and to a greater extent, Cu(gtsm), prevented the formation of infectious chlamydial progeny. Impacts on host cell viability and respiration were also observed in addition to the Chlamydia impacts. This work suggests that copper-based complexes may represent a new lead approach for future development of new therapeutics against chlamydial infections, although host cell impacts need to be fully explored.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tiosemicarbazonas / Chlamydia trachomatis / Cobre / Complejos de Coordinación / Antibacterianos Límite: Humans Idioma: En Revista: Pathog Dis Año: 2017 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tiosemicarbazonas / Chlamydia trachomatis / Cobre / Complejos de Coordinación / Antibacterianos Límite: Humans Idioma: En Revista: Pathog Dis Año: 2017 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos