Acellular pertussis vaccine in adults: adverse reactions and immune response.
Eur J Clin Microbiol
; 6(1): 18-21, 1987 Feb.
Article
en En
| MEDLINE
| ID: mdl-2883004
An acellular pertussis vaccine JNIH-6 containing pertussis toxin and filamentous hemagglutinin was evaluated in adult volunteers with regard to adverse reactions and antibody response. Adverse reactions were few and mild. A late onset local reaction was seen in 22 of the 47 vaccinees (47%) as compared to none of the 20 subjects receiving a placebo, the carrier solution of aluminium phosphate of the vaccine. The reaction, which manifested itself on the 6th to 8th day after vaccination, consisted in all cases of an induration and/or swelling considered insignificant by the majority of the subjects. The reaction was only found in vaccinees receiving a first dose of vaccine and was independent of the prevaccination antitoxin level. The vaccine induced a highly satisfactory antibody response to both filamentous hemagglutinin and pertussis toxin.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Bordetella pertussis
/
Vacuna contra la Tos Ferina
/
Anticuerpos Antibacterianos
Tipo de estudio:
Clinical_trials
Límite:
Adult
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Eur J Clin Microbiol
Año:
1987
Tipo del documento:
Article
Pais de publicación:
Alemania