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Tempol improves lipid profile and prevents left ventricular hypertrophy in LDL receptor gene knockout (LDLr-/-) mice on a high-fat diet.
Viana Gonçalves, Igor Cândido; Cerdeira, Cláudio Daniel; Poletti Camara, Eduardo; Dias Garcia, José Antônio; Ribeiro Pereira Lima Brigagão, Maísa; Bessa Veloso Silva, Roberta; Bitencourt Dos Santos, Gérsika.
Afiliación
  • Viana Gonçalves IC; Faculdade de Medicina, Universidade José do Rosário Vellano (UNIFENAS), Alfenas, MG, Brazil.
  • Cerdeira CD; Departamento de Bioquímica (DBq), Instituto de Ciências Biomédicas, Universidade Federal de Alfenas (UNIFAL-MG), Alfenas, MG, Brazil. Electronic address: daniel.cerdeira.84@gmail.com.
  • Poletti Camara E; Faculdade de Medicina, Universidade José do Rosário Vellano (UNIFENAS), Alfenas, MG, Brazil.
  • Dias Garcia JA; Faculdade de Medicina, Universidade José do Rosário Vellano (UNIFENAS), Alfenas, MG, Brazil.
  • Ribeiro Pereira Lima Brigagão M; Departamento de Bioquímica (DBq), Instituto de Ciências Biomédicas, Universidade Federal de Alfenas (UNIFAL-MG), Alfenas, MG, Brazil.
  • Bessa Veloso Silva R; Faculdade de Medicina, Universidade José do Rosário Vellano (UNIFENAS), Alfenas, MG, Brazil.
  • Bitencourt Dos Santos G; Faculdade de Medicina, Universidade José do Rosário Vellano (UNIFENAS), Alfenas, MG, Brazil.
Rev Port Cardiol ; 36(9): 629-638, 2017 Sep.
Article en En, Pt | MEDLINE | ID: mdl-28826937
INTRODUCTION AND OBJECTIVE: Dyslipidemia is associated with increased risk of cardiovascular disease and atherosclerosis, and hence with high morbidity and mortality. This study investigated the effects of the nitroxide 4-hydroxy-2,2,6,6-tetramethylpiperidine 1-oxyl (Tempol) on lipid profile and cardiac morphology in low-density lipoprotein (LDL) receptor gene knockout (LDLr-/-) mice. METHODS: Male LDLr-/- mice (three months old, approximately 22 g weight) were divided into the following groups: controls, including (1) standard chow (SC, n=8) and (2) high-fat diet (HFD, n=8); and treatment, including (3) standard chow + Tempol (SC+T, n=8) (30 mg/kg administered by gavage, once daily) and (4) high-fat diet + Tempol (HFD+T, n=8) (30 mg/kg). After 30 days of the diet/treatment, whole blood was collected for analysis of biochemical parameters (total cholesterol, triglycerides [TG], high-density lipoprotein [HDL], LDL, and very low-density lipoprotein [VLDL]). The heart was removed through thoracotomy and histological analysis of the left ventricle was performed. RESULTS: A significant increase in TG, LDL, and VLDL and marked left ventricular hypertrophy (LVH) were demonstrated in the HFD group relative to the SC group (p<0.05), while Tempol treatment (HFD+T group) significantly (p<0.05) prevented increases in the levels of these lipid profile markers and attenuated LVH compared with the HFD group. CONCLUSION: In this study, Tempol showed potential for the prevention of events related to serious diseases of the cardiovascular system.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hipertrofia Ventricular Izquierda / Óxidos N-Cíclicos / Metabolismo de los Lípidos / Dieta Alta en Grasa Límite: Animals Idioma: En / Pt Revista: Rev Port Cardiol Asunto de la revista: CARDIOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Portugal
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hipertrofia Ventricular Izquierda / Óxidos N-Cíclicos / Metabolismo de los Lípidos / Dieta Alta en Grasa Límite: Animals Idioma: En / Pt Revista: Rev Port Cardiol Asunto de la revista: CARDIOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Portugal