Your browser doesn't support javascript.
loading
High Sensitivity Cardiac Troponin T and Cognitive Function in the Oldest Old: The Leiden 85-Plus Study.
Bertens, Anne Suzanne; Sabayan, Behnam; de Craen, Anton J M; Van der Mast, Roos C; Gussekloo, Jacobijn.
Afiliación
  • Bertens AS; Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
  • Sabayan B; Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.
  • de Craen AJM; Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.
  • Van der Mast RC; Departments of Medicine and Neurology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.
  • Gussekloo J; Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.
J Alzheimers Dis ; 60(1): 235-242, 2017.
Article en En | MEDLINE | ID: mdl-28826179
BACKGROUND: Impaired cardiac function has been related to accelerated cognitive decline in late-life. OBJECTIVE: To investigate whether higher levels of high sensitivity cardiac troponin T (hs-cTnT), a sensitive marker for myocardial injury, are associated with worse cognitive function in the oldest old. METHODS: In 455 participants of the population-based Leiden 85-plus Study, hs-cTnT was measured at 86 years. Cognitive function was measured annually during four years with the Mini-Mental State Examination (MMSE). RESULTS: Participants in the highest gender-specific tertile of hs-cTnT had a 2.0-point lower baseline MMSE score than participants in the lowest tertile (95% confidence interval (CI) (95% CI 0.73-3.3), and had a 0.58-point steeper annual decline in MMSE during follow-up (95% CI 0.06-1.1). The associations remained after adjusting for sociodemographic and cardiovascular risk factors excluding those without a history of overt cardiac disease. CONCLUSION: In a population-based sample of the oldest old, higher levels of hs-cTnT were associated with worse cognitive function and faster cognitive decline, independently from cardiovascular risk factors and a history of overt cardiac disease.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Envejecimiento / Enfermedades Cardiovasculares / Trastornos del Conocimiento / Troponina T Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Risk_factors_studies Límite: Aged80 / Female / Humans / Male País/Región como asunto: Europa Idioma: En Revista: J Alzheimers Dis Asunto de la revista: GERIATRIA / NEUROLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Envejecimiento / Enfermedades Cardiovasculares / Trastornos del Conocimiento / Troponina T Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Risk_factors_studies Límite: Aged80 / Female / Humans / Male País/Región como asunto: Europa Idioma: En Revista: J Alzheimers Dis Asunto de la revista: GERIATRIA / NEUROLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Países Bajos