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The Phenotype of Circulating Neutrophils during Visceral Leishmaniasis.
Sharma, Smriti; Srivastva, Shweta; Davis, Richard E; Singh, Siddharth Sankar; Kumar, Rajiv; Nylén, Susanne; Wilson, Mary E; Sundar, Shyam.
Afiliación
  • Sharma S; Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
  • Srivastva S; Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
  • Davis RE; Interdisciplinary Program in Immunology, University of Iowa, Iowa City, Iowa.
  • Singh SS; Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
  • Kumar R; Department of Biochemistry, Institute of Science, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
  • Nylén S; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
  • Wilson ME; Veterans' Affairs Medical Center, Iowa City, Iowa.
  • Sundar S; Interdisciplinary Program in Immunology, University of Iowa, Iowa City, Iowa.
Am J Trop Med Hyg ; 97(3): 767-770, 2017 Sep.
Article en En | MEDLINE | ID: mdl-28820688
Visceral leishmaniasis (VL) is a chronic parasitic disease associated with suppressed T cell responses. Although parasites reside intracellularly in macrophages during chronic VL, neutrophils are the first host cell to infiltrate the infection site and phagocytose the parasite. Subsets of neutrophils with unusual characteristics have been documented in human VL, but whether the total neutrophil population is aberrant during disease is not known. Therefore, we examined phenotypic characteristics of unfractionated polymorphonuclear leukocyte (neutrophils) from subjects with active VL, and compared these with neutrophils from healthy controls or subjects who have been treated for VL. The data showed decreased mRNA and diminished amounts of the neutrophil chemoattractant CXCL8 (interleukin [IL]-8), increased IL-10 mRNA and protein, and elevated transcripts encoding arginase-1, which is involved in suppressing T cell responses. Neutrophils from VL subjects showed enhanced capacity to phagocytose Leishmania spp. promastigotes. The results suggest that neutrophils may contribute to immunosuppression in subjects with active VL.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leishmaniasis Visceral / Neutrófilos Límite: Adolescent / Adult / Child / Humans Idioma: En Revista: Am J Trop Med Hyg Año: 2017 Tipo del documento: Article País de afiliación: India Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leishmaniasis Visceral / Neutrófilos Límite: Adolescent / Adult / Child / Humans Idioma: En Revista: Am J Trop Med Hyg Año: 2017 Tipo del documento: Article País de afiliación: India Pais de publicación: Estados Unidos