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Effects of 1,5-anhydroglucitol on postprandial blood glucose and insulin levels and hydrogen excretion in rats and healthy humans.
Nakamura, Sadako; Tanabe, Kenichi; Yoshinaga, Kazuhiro; Shimura, Fumio; Oku, Tsuneyuki.
Afiliación
  • Nakamura S; 1Institute of Food, Nutrition and Health,Jumonji University,2-1-28 Sugasawa,Niiza,Saitama 352-8510,Japan.
  • Tanabe K; 2Department of Food Science and Nutrition,Nagoya Women's University,3-40,Shioji,Mizuho-ku,Nagoya, 467-8610,Japan.
  • Yoshinaga K; 3Nihon Starch Co., Ltd,3-20 Nanei,Kagoshima,891-0196,Japan.
  • Shimura F; 1Institute of Food, Nutrition and Health,Jumonji University,2-1-28 Sugasawa,Niiza,Saitama 352-8510,Japan.
  • Oku T; 1Institute of Food, Nutrition and Health,Jumonji University,2-1-28 Sugasawa,Niiza,Saitama 352-8510,Japan.
Br J Nutr ; 118(2): 81-91, 2017 Jul.
Article en En | MEDLINE | ID: mdl-28820081
The inhibition by 1,5-anhydro-d-glucitol (1,5-AG) was determined on disaccharidases of rats and humans. Then, the metabolism and fate of 1,5-AG was investigated in rats and humans. Although 1,5-AG inhibited about 50 % of sucrase activity in rat small intestine, the inhibition was less than half of d-sorbose. 1,5-AG strongly inhibited trehalase and lactase, whereas d-sorbose inhibited them very weakly. 1,5-AG noncompetitively inhibited sucrase. The inhibition of 1,5-AG on sucrase and maltase was similar between humans and rats. 1,5-AG in serum increased 30 min after oral administration of 1,5-AG (600 mg) in rats, and mostly 100 % of 1,5-AG was excreted into the urine 24 h after administration. 1,5-AG in serum showed a peak 30 min after ingestion of 1,5-AG (20 g) by healthy subjects, and decreased gradually over 180 min. About 60 % of 1,5-AG was excreted into the urine for 9 h following ingestion. Hydrogen was scarcely excreted in both rats and humans 24 h after administration of 1,5-AG. Furthermore, 1,5-AG significantly suppressed the blood glucose elevation, and hydrogen excretion was increased following the simultaneous ingestion of sucrose and 1,5-AG in healthy subjects. 1,5-AG also significantly suppressed the blood glucose elevation following the simultaneous ingestion of glucose and 1,5-AG; however, hydrogen excretion was negligible. The available energy of 1,5-AG, which is absorbed readily from the small intestine and excreted quickly into the urine, is 0 kJ/g (0 kcal/g). Furthermore, 1,5-AG might suppress the blood glucose elevation through the inhibition of sucrase, as well as intestinal glucose absorption.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glucemia / Periodo Posprandial / Desoxiglucosa / Insulina Límite: Adult / Animals / Female / Humans / Male Idioma: En Revista: Br J Nutr Año: 2017 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glucemia / Periodo Posprandial / Desoxiglucosa / Insulina Límite: Adult / Animals / Female / Humans / Male Idioma: En Revista: Br J Nutr Año: 2017 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido