Alterations in serum gastrin levels and antral G- and D-cell population following corticosteroid administration. RIA and immunocytochemical long-term study in guinea pigs.
Digestion
; 36(1): 7-12, 1987.
Article
en En
| MEDLINE
| ID: mdl-2881826
Fourteen guinea pigs were given prednisolone daily for 20 days and 11 for 40 days. Another 20 formed the two control groups. Short-term prednisolone treatment significantly increased serum gastrin levels and antral G-cell population as compared to the control group. The same parameters significantly decreased following 40 days of prednisolone treatment as compared to the group of short-term prednisolone treatment. Forty days of prednisolone treatment significantly increased antral D-cell population as compared to the control and short-term prednisolone treatment groups. It is concluded that hypergastrinaemia and antral G-cell hyperplasia following corticosteroid administration is temporary and is accompanied by antral D-cell hyperplasia.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Antro Pilórico
/
Gastrinas
/
Prednisolona
/
Somatostatina
/
Mucosa Gástrica
Límite:
Animals
Idioma:
En
Revista:
Digestion
Año:
1987
Tipo del documento:
Article
Pais de publicación:
Suiza