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-318C/T polymorphism of the CTLA-4 gene is an independent risk factor for RBC alloimmunization among sickle cell disease patients.
Oliveira, V B; Dezan, M R; Gomes, F C A; Menosi Gualandro, S F; Krieger, J E; Pereira, A C; Marsiglia, J D; Levi, J E; Rocha, V; Mendrone-Junior, A; Sabino, E C; Dinardo, C L.
Afiliación
  • Oliveira VB; Fundação Pró-Sangue Hemocentro de São Paulo, São Paulo, São Paulo, Brazil.
  • Dezan MR; Fundação Pró-Sangue Hemocentro de São Paulo, São Paulo, São Paulo, Brazil.
  • Gomes FCA; Fundação Pró-Sangue Hemocentro de São Paulo, São Paulo, São Paulo, Brazil.
  • Menosi Gualandro SF; Discipline of Hematology, University of São Paulo School of Medicine, São Paulo, São Paulo, Brazil.
  • Krieger JE; Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo School of Medicine, São Paulo, São Paulo, Brazil.
  • Pereira AC; Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo School of Medicine, São Paulo, São Paulo, Brazil.
  • Marsiglia JD; Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo School of Medicine, São Paulo, São Paulo, Brazil.
  • Levi JE; Fundação Pró-Sangue Hemocentro de São Paulo, São Paulo, São Paulo, Brazil.
  • Rocha V; Discipline of Hematology, University of São Paulo School of Medicine, São Paulo, São Paulo, Brazil.
  • Mendrone-Junior A; Fundação Pró-Sangue Hemocentro de São Paulo, São Paulo, São Paulo, Brazil.
  • Sabino EC; Institute of Tropical Medicine, University of São Paulo, São Paulo, São Paulo, Brazil.
  • Dinardo CL; Fundação Pró-Sangue Hemocentro de São Paulo, São Paulo, São Paulo, Brazil.
Int J Immunogenet ; 44(5): 219-224, 2017 Oct.
Article en En | MEDLINE | ID: mdl-28815969
Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) molecule is expressed on T-lymphocyte membrane and negatively influences the antigen-presenting process. Reduced expression of CTLA-4 due to gene polymorphisms is associated with increased risk of autoimmune disorders, whose physiopathology is similar to that of post-transfusion red blood cell (RBC) alloimmunization. Our goal was to evaluate if polymorphisms of CTLA-4 gene that affect protein expression are associated with RBC alloimmunization. This was a case-control study in which 134 sickle cell disease (SCD) patients and 253 non-SCD patients were included. All patients were genotyped for the polymorphisms 49A/G and -318C/T of CTLA-4 gene. The genotype frequency of -318C/T differed significantly between alloimmunized and nonalloimmunized SCD patients, irrespective of clinical confounders (p = .016). SCD patients heterozygous for -318T allele presented higher risk of alloantibody development (OR: 5.4, CI: 1.15-25.6). In conclusion, the polymorphism -318C/T of CTLA-4 gene is associated with RBC alloimmunization among SCD patients. This highlights the role played by CTLA-4 on post-transfusion alloantibody development.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Autoinmunes / Eritrocitos / Antígeno CTLA-4 / Anemia de Células Falciformes Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Int J Immunogenet Asunto de la revista: ALERGIA E IMUNOLOGIA / GENETICA Año: 2017 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Autoinmunes / Eritrocitos / Antígeno CTLA-4 / Anemia de Células Falciformes Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Int J Immunogenet Asunto de la revista: ALERGIA E IMUNOLOGIA / GENETICA Año: 2017 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido