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The Pathogenic A2V Mutant Exhibits Distinct Aggregation Kinetics, Metal Site Structure, and Metal Exchange of the Cu2+ -Aß Complex.
Somavarapu, Arun K; Shen, Fei; Teilum, Kaare; Zhang, Jingdong; Mossin, Susanne; Thulstrup, Peter W; Bjerrum, Morten J; Tiwari, Manish K; Szunyogh, Daniel; Søtofte, Peter M; Kepp, Kasper P; Hemmingsen, Lars.
Afiliación
  • Somavarapu AK; DTU Chemistry, Technical University of Denmark, 2800 Kongens, Lyngby, Denmark.
  • Shen F; Department of Chemistry, University of Copenhagen, Universitetsparken 5, 2100, Copenhagen, Denmark.
  • Teilum K; DTU Chemistry, Technical University of Denmark, 2800 Kongens, Lyngby, Denmark.
  • Zhang J; Structural Biology and NMR Laboratory and the Linderstrøm-Lang Centre for Protein Science, Department of Biology, University of Copenhagen, Ole Maaløes Vej 5, 2200, Copenhagen N, Denmark.
  • Mossin S; DTU Chemistry, Technical University of Denmark, 2800 Kongens, Lyngby, Denmark.
  • Thulstrup PW; DTU Chemistry, Technical University of Denmark, 2800 Kongens, Lyngby, Denmark.
  • Bjerrum MJ; Department of Chemistry, University of Copenhagen, Universitetsparken 5, 2100, Copenhagen, Denmark.
  • Tiwari MK; Department of Chemistry, University of Copenhagen, Universitetsparken 5, 2100, Copenhagen, Denmark.
  • Szunyogh D; Department of Chemistry, University of Copenhagen, Universitetsparken 5, 2100, Copenhagen, Denmark.
  • Søtofte PM; Department of Chemistry, University of Copenhagen, Universitetsparken 5, 2100, Copenhagen, Denmark.
  • Kepp KP; Department of Chemistry, University of Copenhagen, Universitetsparken 5, 2100, Copenhagen, Denmark.
  • Hemmingsen L; DTU Chemistry, Technical University of Denmark, 2800 Kongens, Lyngby, Denmark.
Chemistry ; 23(55): 13591-13595, 2017 Oct 04.
Article en En | MEDLINE | ID: mdl-28815875
A prominent current hypothesis is that impaired metal ion homeostasis may contribute to Alzheimer's disease (AD). We elucidate the interaction of Cu2+ with wild-type (WT) Aß1-40 and the genetic variants A2T and A2V which display increasing pathogenicity as A2T
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Péptidos beta-Amiloides / Cobre Límite: Humans Idioma: En Revista: Chemistry Asunto de la revista: QUIMICA Año: 2017 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Alemania
Texto completo
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Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Péptidos beta-Amiloides / Cobre Límite: Humans Idioma: En Revista: Chemistry Asunto de la revista: QUIMICA Año: 2017 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Alemania