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Age-related reference values for the pediatric Scale for Assessment and Rating of Ataxia: a multicentre study.
Lawerman, Tjitske F; Brandsma, Rick; Burger, Huibert; Burgerhof, Johannes G M; Sival, Deborah A.
Afiliación
  • Lawerman TF; Department of Neurology, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
  • Brandsma R; Department of Neurology, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
  • Burger H; Department of General Medicine, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
  • Burgerhof JGM; Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
  • Sival DA; Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Dev Med Child Neurol ; 59(10): 1077-1082, 2017 10.
Article en En | MEDLINE | ID: mdl-28815574
AIM: For reliable assessment of ataxia severity in children, the Childhood Ataxia and Cerebellar Group of the European Pediatric Neurology Society aimed to validate the Scale for Assessment and Rating of Ataxia (SARA) according to age. METHOD: Twenty-two pediatric ataxia experts from 15 international institutions scored videotaped SARA performances in 156 typically developing children (4-16y: m/f=1; 12 children per year of age; including nine different nationalities). We determined age-dependency and reliability of pediatric SARA scores by a mixed model. RESULTS: In typically developing children, age was the only variable that revealed a relationship with SARA scores (p<0.001). The youngest children revealed the highest scores and the highest variation in scores (<8y; p<0.001). After 11 years of age, pediatric scores approached adult outcomes. The interobserver agreement of total SARA scores was substantial with an intraclass correlation coefficient of 0.63 (95% confidence interval 0.56-0.69; p<0.001). INTERPRETATION: In typically developing European children, both SARA scores and interobserver agreement are age-dependent. For reliable interpretation of pediatric SARA scores, consideration of the underlying test construct appears prudent. These data will hopefully contribute to a correct and uniform interpretation of longitudinal SARA scores from childhood to adulthood.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ataxia / Índice de Severidad de la Enfermedad Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Male País/Región como asunto: Europa Idioma: En Revista: Dev Med Child Neurol Año: 2017 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ataxia / Índice de Severidad de la Enfermedad Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Male País/Región como asunto: Europa Idioma: En Revista: Dev Med Child Neurol Año: 2017 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido