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Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for pseudomyxoma peritonei and appendix tumours in elderly patients: Is it justified?
López-López, V; Cascales-Campos, P A; Gil, E; Arevalo, J; Gonzalez, A; Gil, J; Muñoz-Casares, F C; Melero, J T; Barrios, P; Morales, R; Ramos, I; Ortega, G; Camps, B; González-Bayón, L; Bretcha-Boix, P; Farré-Alegre, J; González-Moreno, S; Parrilla, P.
Afiliación
  • López-López V; Surgery Department, Clinic Universitary Hospital of Virgen De La Arrixaca, IMIB, Arrixaca, Carretera Madrid-Cartagena S/N. El Palmar, 30120, Murcia, Spain.
  • Cascales-Campos PA; Surgery Department, Clinic Universitary Hospital of Virgen De La Arrixaca, IMIB, Arrixaca, Carretera Madrid-Cartagena S/N. El Palmar, 30120, Murcia, Spain. cascalescirugia@gmail.com.
  • Gil E; Surgery Department, Clinic Universitary Hospital of Virgen De La Arrixaca, IMIB, Arrixaca, Carretera Madrid-Cartagena S/N. El Palmar, 30120, Murcia, Spain.
  • Arevalo J; Radiology Departament, Memorial Sloan Kettering Cancer Center, New York, USA.
  • Gonzalez A; Surgery Department, Clinic Universitary Hospital of Virgen De La Arrixaca, IMIB, Arrixaca, Carretera Madrid-Cartagena S/N. El Palmar, 30120, Murcia, Spain.
  • Gil J; Surgery Department, Clinic Universitary Hospital of Virgen De La Arrixaca, IMIB, Arrixaca, Carretera Madrid-Cartagena S/N. El Palmar, 30120, Murcia, Spain.
  • Muñoz-Casares FC; Hospital Universitario Virgen del Rocio, Sevilla, Andalucia, Spain.
  • Melero JT; Hospital Universitario De Torrecárdenas, Almería, Andalucia, Spain.
  • Barrios P; Hospital De Sant Joan De Espi Moises Broggi, Sant Joan De Espi, Cataluña, Spain.
  • Morales R; Hospital Universitario Son Espases, Palma de Mayorca, Islas Baleares, Spain.
  • Ramos I; Hospital De Sant Joan De Espi Moises Broggi, Sant Joan De Espi, Cataluña, Spain.
  • Ortega G; Hospital Universitario De Fuenlabrada, Madrid, Spain.
  • Camps B; Hospital General Universitario Valencia, Valencia, Spain.
  • González-Bayón L; Hospital General Universitario Gregorio Marañón, Madrid, Spain.
  • Bretcha-Boix P; Hospital Quirón de Torrevieja, Alicante, Comunidad Valenciana, Spain.
  • Farré-Alegre J; Hospital Quirón de Torrevieja, Alicante, Comunidad Valenciana, Spain.
  • González-Moreno S; MD Anderson Cancer Center, Madrid, Spain.
  • Parrilla P; Surgery Department, Clinic Universitary Hospital of Virgen De La Arrixaca, IMIB, Arrixaca, Carretera Madrid-Cartagena S/N. El Palmar, 30120, Murcia, Spain.
Clin Transl Oncol ; 19(11): 1388-1392, 2017 Nov.
Article en En | MEDLINE | ID: mdl-28812240
BACKGROUND: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) for pseudomyxoma peritonei and appendix tumours are widespread in the world. It is unclear what should be the attitude in elderly patients. METHODS: This retrospective multicenter study collected the database from ten Spanish centers from Spanish Group of Peritoneal Cancer Surgery. The study period was between November 2002 and March 2014. Seventeen patients with age greater than or equal to 75 years with peritoneal carcinomatosis from pseudomyxoma peritonei and appendix tumours met the selection criteria for the study. Outcomes in terms of morbidity and mortality such as disease-free and overall survival were analyzed. RESULTS: Median PCI was 16 (range 6-39). Ten postoperative adverse events were detected in nine patients (44.4%). 28% were grade I-II and 17% were grade III-IV. Disease-free survival at 1 and 3 years was 67 and 44%, respectively. Overall survival at 1 and 3 years was 100 and 88%, respectively. Only cytoreduction was related to worst disease free survival after univariate (p = 0.007) and multivariate (OR 11.639, 95% CI 1.24-109.74, p = 0.03) analyses. Cytoreduction was related to the worst overall survival after univariate analysis (p = 0.046). CONCLUSION: Cytoreductive surgery and HIPEC for pseudomyxoma peritonei and appendix tumours in elderly patients it is a procedure with feasible postoperative morbi-mortality and survival outcomes. TRIAL REGISTRATION: researchregistry1587 (retrospectively registered).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias del Apéndice / Neoplasias Peritoneales / Seudomixoma Peritoneal / Quimioterapia del Cáncer por Perfusión Regional / Protocolos de Quimioterapia Combinada Antineoplásica / Procedimientos Quirúrgicos de Citorreducción / Hipertermia Inducida Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Clin Transl Oncol Año: 2017 Tipo del documento: Article País de afiliación: España Pais de publicación: Italia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias del Apéndice / Neoplasias Peritoneales / Seudomixoma Peritoneal / Quimioterapia del Cáncer por Perfusión Regional / Protocolos de Quimioterapia Combinada Antineoplásica / Procedimientos Quirúrgicos de Citorreducción / Hipertermia Inducida Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Clin Transl Oncol Año: 2017 Tipo del documento: Article País de afiliación: España Pais de publicación: Italia