Your browser doesn't support javascript.
loading
Effects of Sodium Houttuyfonate on Pulmonary Inflammation in COPD Model Rats.
Wu, Zhonghua; Tan, Bo; Zhang, Haiying; Guo, Yinuo; Tu, Yanjie; Qiu, Furong; Yang, Aidong.
Afiliación
  • Wu Z; Department of Febrile Disease, Basic Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
  • Tan B; Department of Experiment Center for Science and Technology, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
  • Zhang H; Clinical Pharmacokinetic Laboratory, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
  • Guo Y; Department of Febrile Disease, Basic Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
  • Tu Y; Department of Febrile Disease, Basic Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
  • Qiu F; Department of Febrile Disease, Basic Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
  • Yang A; Clinical Pharmacokinetic Laboratory, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China. furong_qiu@126.com.
Inflammation ; 40(6): 2109-2117, 2017 Dec.
Article en En | MEDLINE | ID: mdl-28812176
The anti-inflammatory effect of sodium houttuyfonate (SH), an herbal-originated drug that used in China clinically, was investigated on chronic obstructive pulmonary disease (COPD) inflammatory model rats induced by combination usage of cigarette smoke (CS) and lipopolysaccharide (LPS). The morphology of the lung tissue, the expression levels of cytokines in the bronchoalveolar lavage fluid (BALF), the protein levels of TLR4, NF-κB p65, and SIGIRR, and the mRNA levels of TLR4, MyD88, NF-κB p65, and SIGIRR in lung tissues were investigated, respectively. After treated by SH (24.3 mg/kg), the abnormal morphology changes of lung tissues in COPD rats, such as neutrophil infiltration and airway obstruction, were considerably alleviated, as well as both proinflammatory cytokines, TNF-α and IL-1ß, significantly decreased in BALF. The mRNA level of TLR4, MyD88, and NF-κB p65 and protein expression of TLR4 and NF-κB p65 in lung tissues decreased significantly after SH treatment, while both SIGIRR mRNA and protein levels increased significantly. These results suggest that SH markedly attenuated the pulmonary inflammation induced by CS and LPS and protected the lung tissue in COPD model rat. The anti-inflammatory effects were related to suppress the TLR4/NF-κB pathway dependent on MyD88. TIR8/SIGIRR might contribute to the protective effects of SH on pulmonary inflammation.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neumonía / Sulfitos / Enfermedad Pulmonar Obstructiva Crónica / Alcanos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Inflammation Año: 2017 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neumonía / Sulfitos / Enfermedad Pulmonar Obstructiva Crónica / Alcanos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Inflammation Año: 2017 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos