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Risk factors for infective endocarditis in children with congenital heart diseases - A nationwide population-based case control study.
Sun, Li-Chuan; Lai, Chih-Cheng; Wang, Cheng-Yi; Wang, Ya-Hui; Wang, Jen-Yu; Hsu, Yo-Ling; Hu, Yin-Lan; Wu, En-Ting; Lin, Ming-Tai; Sy, Leticia B; Chen, Likwang.
Afiliación
  • Sun LC; Department of Pediatrics, Cardinal Tien Hospital and School of Medicine, Colloge of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan.
  • Lai CC; Department of Intensive Care Medicine, Chi Mei Medical Center, Liouying, Tainan, Taiwan.
  • Wang CY; Department of Internal Medicine, Cardinal Tien Hospital and School of Medicine, Colloge of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan.
  • Wang YH; Medical Research Center, Cardinal Tien Hospital and School of Medicine, Colloge of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan.
  • Wang JY; Department of Internal Medicine, Cardinal Tien Hospital and School of Medicine, Colloge of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan.
  • Hsu YL; Department of Pediatrics, Cardinal Tien Hospital and School of Medicine, Colloge of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan.
  • Hu YL; Department of Dentistry, Cardinal Tien Hospital and School of Medicine, Colloge of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan.
  • Wu ET; Department of Pediatrics, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan.
  • Lin MT; Department of Pediatrics, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan.
  • Sy LB; Department of Pediatrics, Cardinal Tien Hospital and School of Medicine, Colloge of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan. Electronic address: dikoletty123@mospital.com.
  • Chen L; Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Miaoli County, Taiwan. Electronic address: likwang@nhri.org.tw.
Int J Cardiol ; 248: 126-130, 2017 Dec 01.
Article en En | MEDLINE | ID: mdl-28811093
BACKGROUND: Infective endocarditis (IE) is uncommon in childhood. Its associated epidemiological characteristics in patients with congenital heart disease (CHD) remain unclear. METHODS: The study population included children born in Taiwan during the years 1997 to 2005 who were diagnosed as having CHD before 3years of age. All children were followed up until the end year of 2010, the diagnosis of infective endocarditis, or death. The demographic characteristics of patients with and without IE, the invasive procedures performed during 6months before the index date, the prophylactic antibiotics related to dental procedures, and in-hospital mortality were collected. RESULTS: Information of 24,729 children with CHD were retrieved for our analysis and 237 patients with newly diagnosed IE were identified. The incidence rate of IE in all CHD lesions was 11.13 per 10,000person-years. Taking ASD for reference, the following CHD lesions were at risk for IE: cyanotic CHD (adjusted OR, 9.58; 95% confidence interval, 5.38-17.05), endocardial cushion defect (ECD) (8.01; 2.73-23.50), Left-sided lesions (4.36; 1.90-10.01) and VSD (2.93; 1.64-5.23). Patients who underwent procedures have a higher risk of acquiring IE which include central venous catheter (CVC) insertion (3.17; 2.36-4.27), cardiac catheterization (3.74; 2.67-5.22), open-heart surgery (2.47; 1.61-3.77), valve surgery (3.20; 1.70-6.02), and shunt surgery (7.43; 2.36-23.41). However, dental procedures did not increase the risk of IE, irrespective of antibiotic usage. CONCLUSIONS: The risk of IE varies markedly among CHD lesions in our study. Invasive heart procedures but not dental procedures, are more significantly associated with IE among children with CHD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vigilancia de la Población / Endocarditis / Cardiopatías Congénitas Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Límite: Child / Child, preschool / Female / Humans / Infant / Male / Newborn País/Región como asunto: Asia Idioma: En Revista: Int J Cardiol Año: 2017 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vigilancia de la Población / Endocarditis / Cardiopatías Congénitas Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Límite: Child / Child, preschool / Female / Humans / Infant / Male / Newborn País/Región como asunto: Asia Idioma: En Revista: Int J Cardiol Año: 2017 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Países Bajos