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Comparison of the therapeutic effects of sildenafil citrate, heparin and neuropeptides in a rat model of acetic acid-induced gastric ulcer.
Kalayci, Mehmet; Kocdor, Mehmet Ali; Kuloglu, Tuncay; Sahin, Ibrahim; Sarac, Mehmet; Aksoy, Aziz; Yardim, Meltem; Dalkilic, Semih; Gursu, Onur; Aydin, Suna; Akkoc, Ramazan Fazil; Ugras, Meltem; Artas, Gokhan; Ozercan, Ibrahim Hanifi; Ugur, Kader; Aydin, Suleyman.
Afiliación
  • Kalayci M; Department of Medical Biochemistry and Clinical Biochemistry, (Firat Hormones Research Group), Medical School, Firat University, 23119 Elazig, Turkey.
  • Kocdor MA; Department of General Surgery, Medical School, Dokuz Eylul University, 35340 Izmir, Turkey.
  • Kuloglu T; Department of Histology and Embryology, Medical School, Firat University, 23119 Elazig, Turkey.
  • Sahin I; Department of Medical Biochemistry and Clinical Biochemistry, (Firat Hormones Research Group), Medical School, Firat University, 23119 Elazig, Turkey; Department of Histology and Embryology, Medical School, Erzincan University, 24100 Erzincan, Turkey.
  • Sarac M; Department of Pediatric Surgery, Medical School, Firat University, 23119 Elazig, Turkey.
  • Aksoy A; Department of Nutrition and Dietetics, Bitlis Eren University, 13000 Bitlis, Turkey.
  • Yardim M; Department of Medical Biochemistry and Clinical Biochemistry, (Firat Hormones Research Group), Medical School, Firat University, 23119 Elazig, Turkey.
  • Dalkilic S; Department of Molecular Biology, Life Science Faculty, Firat University, 23119 Elazig, Turkey.
  • Gursu O; Department of Internal Medicine, Umraniye Education and Research Hospital, Health Science University, 34764 Istanbul, Turkey.
  • Aydin S; Department of Anatomy, Medical School, Firat University, 23119 Elazig, Turkey.
  • Akkoc RF; Department of Anatomy, Medical School, Firat University, 23119 Elazig, Turkey.
  • Ugras M; Department of Pediatrics, Medical School, Yeditepe University, 34755 Istanbul, Turkey.
  • Artas G; Department of Pathology, Medical School, Firat University, 23119 Elazig, Turkey.
  • Ozercan IH; Department of Pathology, Medical School, Firat University, 23119 Elazig, Turkey.
  • Ugur K; Department of Internal Medicine, Medical School, Firat University, 23119 Elazig, Turkey.
  • Aydin S; Department of Medical Biochemistry and Clinical Biochemistry, (Firat Hormones Research Group), Medical School, Firat University, 23119 Elazig, Turkey. Electronic address: saydin1@hotmail.com.
Life Sci ; 186: 102-110, 2017 Oct 01.
Article en En | MEDLINE | ID: mdl-28807720
AIMS: The purpose of our investigative work has been to determine whether there can be therapeutic roles in the administration of sildenafil citrate, heparin and several neuropeptides on an animal model where gastric ulcers were induced with acetic acid, and to compare their efficacy. MATERIALS AND METHODS: The animals were divided into 13 groups, with 4 animals in each. Gastric ulcers was induced in the animals of 12 groups with one untreated group being left as the control (Group I - control; given normal saline (NS)). The other groups were: Group II (ulcer+NS); Group III (5mg/kg sildenafil citrate, low dose); Group IV (10mg/kg sildenafil citrate, high dose); Group V (0.6mg/kg heparin, low dose); Group VI (6mg/kg heparin, high dose); Group VII (20nmol/kg des-acyl ghrelin); Group VIII (40nmol/kg des-acyl ghrelin); Group IX (4nmol/kg acyl ghrelin); Group X (8nmol/kg acly ghrelin); Group XI (20pmol/kg Nesfatin-1); Group XII (15nmol/kg Obestatin) and Group XIII (5nmol/kg Neuropeptide Y). Gastric neuropeptide expression was measured using an immunohistochemical method, and the amount in circulation was detected using ELISA. To compare with no treatment, the controls and other treatment groups, we recorded loss of the surface epithelium of the stomach, erosion, bleeding and inflammatory cell infiltration in the upper halves of the gastric glands. KEY FINDINGS: The muscularis and the layers beneath it were, however, apparently normal. The gastric mucosa healed with little or no inflammation when sildenafil citrate, low dose heparin, ghrelin, NUCB2/Nesfatin-1, obestatin, Neuropeptide Y were administered. SIGNIFICANCE: Overall the data indicate that low dose heparin, and especially sildenafil citrate and neuropeptides, can be used clinically as an alternative approach in the treatment of the gastric ulcer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Úlcera Gástrica / Neuropéptidos / Heparina / Citrato de Sildenafil / Antiulcerosos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Life Sci Año: 2017 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Úlcera Gástrica / Neuropéptidos / Heparina / Citrato de Sildenafil / Antiulcerosos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Life Sci Año: 2017 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Países Bajos