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Targeting signal transducers and activators of transcription (STAT) in human cancer by dietary polyphenolic antioxidants.
Amani, Hamed; Ajami, Marjan; Nasseri Maleki, Solmaz; Pazoki-Toroudi, Hamidreza; Daglia, Maria; Tsetegho Sokeng, Arold Jorel; Di Lorenzo, Arianna; Nabavi, Seyed Fazel; Devi, Kasi Pandima; Nabavi, Seyed Mohammad.
Afiliación
  • Amani H; Department of Medical Nanotechnology, Faculty of Advanced Technologies in Medicine, Iran University of Medical Science, Tehran, Iran.
  • Ajami M; National Nutrition and Food Technology Research Institute, Faculty of Nutrition Science and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Nasseri Maleki S; Physiology Research Center, Department of Physiology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
  • Pazoki-Toroudi H; Physiology Research Center, Department of Physiology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
  • Daglia M; Department of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology Section, University of Pavia, Via Taramelli 12, 27100, Pavia, Italy. Electronic address: maria.daglia@unipv.it.
  • Tsetegho Sokeng AJ; Department of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology Section, University of Pavia, Via Taramelli 12, 27100, Pavia, Italy.
  • Di Lorenzo A; Department of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology Section, University of Pavia, Via Taramelli 12, 27100, Pavia, Italy.
  • Nabavi SF; Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, 19395-5487, Iran.
  • Devi KP; Department of Biotechnology, Alagappa University, Karaikudi, 630004, Tamil Nadu, India.
  • Nabavi SM; Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, 19395-5487, Iran. Electronic address: Nabavi208@gmail.com.
Biochimie ; 142: 63-79, 2017 Nov.
Article en En | MEDLINE | ID: mdl-28807562
Over the course of the last three decades, a large body of evidence has shown that polyphenols, the secondary metabolites occurring in plant foods and beverages, exert protective effects due to their antioxidant activity mediated through different mechanisms ranging from direct radical scavenging and metal chelating activities, to the capacity to inhibit pro-oxidant enzymes and to target specific cell-signalling pathways. In the last decade, dietary components, and polyphenols in particular have gained considerable attention as chemopreventive agents against different types of cancer. The signal transducers and activators of transcription (STAT) family is a group of cytoplasmic transcription factors which interact with specific sequences of DNA, inducing the expression of specific genes which in turn give rise to adaptive and highly specific biological responses. Growing evidence suggests that, of the seven STAT members identified, STAT3 is over-expressed in many human tumors (i.e. solid tumors and hematological malignancies) promoting the onset and development of cancer in humans by inhibiting apoptosis or by inducing cell proliferation, angiogenesis, invasion, and metastasis. This review article aims to assess the most recent studies on the role of STATs, with focus on STAT3, in oncogenesis, and the promising effects of some polyphenols on STAT expression. Moreover, the mechanisms behind the anti-inflammatory and antioxidant activities of polyphenols which have an influence on STAT expression are discussed, with a focus on their ability to target specific cell-signalling pathways.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dieta / Factor de Transcripción STAT3 / Terapia Molecular Dirigida / Polifenoles / Neoplasias / Antioxidantes Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Biochimie Año: 2017 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Francia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dieta / Factor de Transcripción STAT3 / Terapia Molecular Dirigida / Polifenoles / Neoplasias / Antioxidantes Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Biochimie Año: 2017 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Francia