Methylation of DNA Ligase 1 by G9a/GLP Recruits UHRF1 to Replicating DNA and Regulates DNA Methylation.

Ferry, Laure; Fournier, Alexandra; Tsusaka, Takeshi; Adelmant, Guillaume; Shimazu, Tadahiro; Matano, Shohei; Kirsh, Olivier; Amouroux, Rachel; Dohmae, Naoshi; Suzuki, Takehiro; Filion, Guillaume J; Deng, Wen; de Dieuleveult, Maud; Fritsch, Lauriane; Kudithipudi, Srikanth; Jeltsch, Albert; Leonhardt, Heinrich; Hajkova, Petra; Marto, Jarrod A; Arita, Kyohei; Shinkai, Yoichi; Defossez, Pierre-Antoine

Ferry, Laure; Fournier, Alexandra; Tsusaka, Takeshi; Adelmant, Guillaume; Shimazu, Tadahiro; Matano, Shohei; Kirsh, Olivier; Amouroux, Rachel; Dohmae, Naoshi; Suzuki, Takehiro; Filion, Guillaume J; Deng, Wen; de Dieuleveult, Maud; Fritsch, Lauriane; Kudithipudi, Srikanth; Jeltsch, Albert; Leonhardt, Heinrich; Hajkova, Petra; Marto, Jarrod A; Arita, Kyohei; Shinkai, Yoichi; Defossez, Pierre-Antoine.

Afiliación

Ferry L; Epigenetics and Cell Fate, University Paris Diderot, Sorbonne Paris Cité, UMR 7216 CNRS, 75013 Paris, France.
Fournier A; Epigenetics and Cell Fate, University Paris Diderot, Sorbonne Paris Cité, UMR 7216 CNRS, 75013 Paris, France.
Tsusaka T; Cellular Memory Laboratory, RIKEN Wako, Saitama 351-0198, Japan; Graduate School of Medicine, Diabetes, Endocrinology, and Nutrition, Kyoto University, Kyoto 606-8507, Japan.
Adelmant G; The Blais Proteomics Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
Shimazu T; Cellular Memory Laboratory, RIKEN Wako, Saitama 351-0198, Japan.
Matano S; Department of Medical Life Sciences, Yokohama City University, Yokohama 230-0045, Japan.
Kirsh O; Epigenetics and Cell Fate, University Paris Diderot, Sorbonne Paris Cité, UMR 7216 CNRS, 75013 Paris, France.
Amouroux R; MRC Clinical Sciences Centre (CSC), Du Cane Road, London W12 0NN, UK; Faculty of Medicine, Institute of Clinical Sciences (ICS), Imperial College London, Du Cane Road, London W12 0NN, UK.
Dohmae N; Biomolecular Characterization Unit, Center for Sustainable Resource Science, RIKEN, Wako, Saitama 351-0198, Japan.
Suzuki T; Biomolecular Characterization Unit, Center for Sustainable Resource Science, RIKEN, Wako, Saitama 351-0198, Japan.
Filion GJ; Centre for Genomic Regulation (CRG), The Barcelona Institute for Science and Technology, 08003 Barcelona, Spain; Universitat Pompeu Fabra (UPF), 08002 Barcelona, Spain.
Deng W; Department of Biology II and Center for Integrated Protein Science Munich (CIPSM), Ludwig-Maximilians-Universität München, 82152 Planegg-Martinsried, Germany.
de Dieuleveult M; Epigenetics and Cell Fate, University Paris Diderot, Sorbonne Paris Cité, UMR 7216 CNRS, 75013 Paris, France.
Fritsch L; Epigenetics and Cell Fate, University Paris Diderot, Sorbonne Paris Cité, UMR 7216 CNRS, 75013 Paris, France.
Kudithipudi S; Institut für Biochemie, Stuttgart University, 70569 Stuttgart, Germany.
Jeltsch A; Institut für Biochemie, Stuttgart University, 70569 Stuttgart, Germany.
Leonhardt H; Department of Biology II and Center for Integrated Protein Science Munich (CIPSM), Ludwig-Maximilians-Universität München, 82152 Planegg-Martinsried, Germany.
Hajkova P; MRC Clinical Sciences Centre (CSC), Du Cane Road, London W12 0NN, UK; Faculty of Medicine, Institute of Clinical Sciences (ICS), Imperial College London, Du Cane Road, London W12 0NN, UK.
Marto JA; The Blais Proteomics Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
Arita K; Department of Medical Life Sciences, Yokohama City University, Yokohama 230-0045, Japan.
Shinkai Y; Cellular Memory Laboratory, RIKEN Wako, Saitama 351-0198, Japan. Electronic address: yshinkai@riken.jp.
Defossez PA; Epigenetics and Cell Fate, University Paris Diderot, Sorbonne Paris Cité, UMR 7216 CNRS, 75013 Paris, France. Electronic address: pierre-antoine.defossez@univ-paris-diderot.fr.

Mol Cell ; 67(4): 550-565.e5, 2017 Aug 17.

Article en En | MEDLINE | ID: mdl-28803780

Asunto(s)

Proteínas Potenciadoras de Unión a CCAAT/metabolismo; ADN Ligasa (ATP)/metabolismo; Metilación de ADN; Replicación del ADN; ADN/biosíntesis; Epigénesis Genética; Antígenos de Histocompatibilidad/metabolismo; N-Metiltransferasa de Histona-Lisina/metabolismo; Procesamiento Proteico-Postraduccional; Animales; Proteínas Potenciadoras de Unión a CCAAT/química; Proteínas Potenciadoras de Unión a CCAAT/genética; ADN/genética; ADN Ligasa (ATP)/química; ADN Ligasa (ATP)/genética; Células Madre Embrionarias/enzimología; Células HEK293; Células HeLa; Antígenos de Histocompatibilidad/química; Antígenos de Histocompatibilidad/genética; N-Metiltransferasa de Histona-Lisina/química; N-Metiltransferasa de Histona-Lisina/genética; Histonas/metabolismo; Humanos; Lisina; Metilación; Ratones; Modelos Moleculares; Imitación Molecular; Mutación; Unión Proteica; Conformación Proteica; Relación Estructura-Actividad; Transfección; Dominio Tudor; Ubiquitina-Proteína Ligasas

Palabras clave

DNA methylation; DNA replication; G9a(Ehmt2)/GLP(Ehmt1); UHRF1; epigenetics; lysine methylation

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ADN / Procesamiento Proteico-Postraduccional / N-Metiltransferasa de Histona-Lisina / Metilación de ADN / Proteínas Potenciadoras de Unión a CCAAT / Epigénesis Genética / Replicación del ADN / ADN Ligasa (ATP) / Antígenos de Histocompatibilidad Límite: Animals / Humans Idioma: En Revista: Mol Cell Asunto de la revista: BIOLOGIA MOLECULAR Año: 2017 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos

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