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PTPN2 regulates T cell lineage commitment and αß versus γδ specification.
Wiede, Florian; Dudakov, Jarrod A; Lu, Kun-Hui; Dodd, Garron T; Butt, Tariq; Godfrey, Dale I; Strasser, Andreas; Boyd, Richard L; Tiganis, Tony.
Afiliación
  • Wiede F; Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia Florian.Wiede@monash.edu.
  • Dudakov JA; Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia.
  • Lu KH; Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia.
  • Dodd GT; Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
  • Butt T; Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia.
  • Godfrey DI; Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
  • Strasser A; Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia.
  • Boyd RL; Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
  • Tiganis T; Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia.
J Exp Med ; 214(9): 2733-2758, 2017 Sep 04.
Article en En | MEDLINE | ID: mdl-28798028
In the thymus, hematopoietic progenitors commit to the T cell lineage and undergo sequential differentiation to generate diverse T cell subsets, including major histocompatibility complex (MHC)-restricted αß T cell receptor (TCR) T cells and non-MHC-restricted γδ TCR T cells. The factors controlling precursor commitment and their subsequent maturation and specification into αß TCR versus γδ TCR T cells remain unclear. Here, we show that the tyrosine phosphatase PTPN2 attenuates STAT5 (signal transducer and activator of transcription 5) signaling to regulate T cell lineage commitment and SRC family kinase LCK and STAT5 signaling to regulate αß TCR versus γδ TCR T cell development. Our findings identify PTPN2 as an important regulator of critical checkpoints that dictate the commitment of multipotent precursors to the T cell lineage and their subsequent maturation into αß TCR or γδ TCR T cells.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfocitos T / Receptores de Antígenos de Linfocitos T gamma-delta / Receptores de Antígenos de Linfocitos T alfa-beta / Linaje de la Célula / Proteína Tirosina Fosfatasa no Receptora Tipo 2 Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Exp Med Año: 2017 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfocitos T / Receptores de Antígenos de Linfocitos T gamma-delta / Receptores de Antígenos de Linfocitos T alfa-beta / Linaje de la Célula / Proteína Tirosina Fosfatasa no Receptora Tipo 2 Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Exp Med Año: 2017 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos