Modeling Glaucoma: Retinal Ganglion Cells Generated from Induced Pluripotent Stem Cells of Patients with SIX6 Risk Allele Show Developmental Abnormalities.

Teotia, Pooja; Van Hook, Matthew J; Wichman, Christopher S; Allingham, R Rand; Hauser, Michael A; Ahmad, Iqbal

Teotia, Pooja; Van Hook, Matthew J; Wichman, Christopher S; Allingham, R Rand; Hauser, Michael A; Ahmad, Iqbal.

Afiliación

Teotia P; Department of Ophthalmology and Visual Sciences, College of Public Health, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Van Hook MJ; Department of Ophthalmology and Visual Sciences, College of Public Health, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Wichman CS; Department of Biostatistics, College of Public Health, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Allingham RR; Department of Ophthalmology, Duke University School of Medicine, Durham, North Carolina, USA.
Hauser MA; Department of Ophthalmology, Duke University School of Medicine, Durham, North Carolina, USA.
Ahmad I; Department of Ophthalmology and Visual Sciences, College of Public Health, University of Nebraska Medical Center, Omaha, Nebraska, USA.

Stem Cells ; 35(11): 2239-2252, 2017 11.

Article en En | MEDLINE | ID: mdl-28792678

Asunto(s)

Glaucoma/genética; Proteínas de Homeodominio/genética; Células Madre Pluripotentes Inducidas/metabolismo; Células Ganglionares de la Retina/metabolismo; Transactivadores/genética; Alelos; Diferenciación Celular; Femenino; Expresión Génica; Glaucoma/fisiopatología; Humanos; Masculino; Células Ganglionares de la Retina/patología

Palabras clave

Glaucoma; In vitro disease modeling/patient specific Induced pluripotent stem cell; RNA-Seq; Retinal ganglion cells; SIX6

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Ganglionares de la Retina / Transactivadores / Glaucoma / Proteínas de Homeodominio / Células Madre Pluripotentes Inducidas Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male Idioma: En Revista: Stem Cells Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido

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