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Serum homocysteine levels in patients with probable vascular dementia.
Alajbegovic, Salem; Lepara, Orhan; Hadzovic-Dzuvo, Almira; Mutevelic-Turkovic, Alma; Alajbegovic, Lejla; Zaciragic, Asija; Avdagic, Nesina; Valjevac, Amina; Babic, Nermina; Dervisevic, Amela.
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  • Alajbegovic S; Department of Endocrinology and Diabetes, Cantonal Hospital, Zenica, Bosnia and Herzegovina.
  • Lepara O; Department of Human Physiology, School of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
  • Hadzovic-Dzuvo A; Department of Human Physiology, School of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
  • Mutevelic-Turkovic A; Department of Human Physiology, School of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
  • Alajbegovic L; Representative office of Berlin-Chemie AG in Sarajevo; Bosnia and Herzegovina.
  • Zaciragic A; Department of Human Physiology, School of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
  • Avdagic N; Department of Human Physiology, School of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
  • Valjevac A; Department of Human Physiology, School of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
  • Babic N; Department of Human Physiology, School of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
  • Dervisevic A; Department of Human Physiology, School of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
Med Glas (Zenica) ; 14(2): 257-261, 2017 Aug 01.
Article en En | MEDLINE | ID: mdl-28786967
Aim To investigate total homocysteine (tHcy) serum concentration in patients with probable vascular dementia (VD) and in agematched controls, as well as to determine an association between tHcy serum concentration and cognitive impairment in patients with probable VD. Methods Serum concentration of tHcy was determined by the Fluorescence Polarization Immunoassay on the AxSYM System. Cognitive impairment was tested by the Mini Mental Status Examination (MMSE) score. Body mass index (BMI) was calculated for each subject included in the study. Results Age, systolic, diastolic blood pressure and BMI did not differ significantly between the two groups. Mean serum tHcy concentration in the control group of subjects was 13.35 µmol/L, while in patients with probable VD it was significantly higher, 19.45 µmol/L (p=0.002). A negative but insignificant association between serum tHcy concentration and cognitive impairment in patients with probable VD was found. Conclusion Increased tHcy concentration in patients with probable VD suggests the possible independent role of Hcy in the pathogenesis of VD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Demencia Vascular / Homocisteína Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Med Glas (Zenica) Asunto de la revista: CIENCIAS DA NUTRICAO / MEDICINA Año: 2017 Tipo del documento: Article Pais de publicación: Bosnia-Herzegovina
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Demencia Vascular / Homocisteína Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Med Glas (Zenica) Asunto de la revista: CIENCIAS DA NUTRICAO / MEDICINA Año: 2017 Tipo del documento: Article Pais de publicación: Bosnia-Herzegovina