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Thermo-and pH-sensitive hydrogel membranes composed of poly(N-isopropylacrylamide)-hyaluronan for biomedical applications: Influence of hyaluronan incorporation on the membrane properties.
Kamoun, Elbadawy A; Fahmy, Alaa; Taha, Tarek H; El-Fakharany, Esmail M; Makram, Mohamed; Soliman, Hesham M A; Shehata, Hassan.
Afiliación
  • Kamoun EA; Polymeric Materials Research Dep., Advanced Technology and New Materials Research Institute (ATNMRI), City of Scientific Research and Technological Applications (SRTA-City), New Borg Al-Arab, Alexandria 21934, Egypt. Electronic address: badawykamoun@yahoo.com.
  • Fahmy A; Chemistry Dep., Faculty of Science, Al-Azhar University, Cairo 11884, Egypt.
  • Taha TH; Environmental Biotechnology Dep., GEBRI, City of Scientific Research and Technological Applications (SRTA-City), New Borg Al-Arab, Alexandria 21934, Egypt.
  • El-Fakharany EM; Therapeutic and Protective Proteins Laboratory, Protein Research Dep., Genetic Engineering and Biotechnology Research Institute (GEBRI), City of Scientific Research and Technological Applications (SRTA-City), New Borg Al-Arab, Alexandria 21934, Egypt.
  • Makram M; Chemistry Dep., Faculty of Science, Al-Azhar University, Cairo 11884, Egypt.
  • Soliman HMA; Nanotechnology and Composite Materials Research Dep., Advanced Technology and New Materials Research Institute (ATNMRI), City of Scientific Research and Technological Applications (SRTA-City), New Borg Al-Arab, Alexandria 21934, Egypt.
  • Shehata H; Chemistry Dep., Faculty of Science, Al-Azhar University, Cairo 11884, Egypt.
Int J Biol Macromol ; 106: 158-167, 2018 Jan.
Article en En | MEDLINE | ID: mdl-28780413
Interpenetrating hydrogel membranes consisting of pH-sensitive hyaluronan (HA) and thermo-sensitive poly(N-isopropylacrylamide) (PNIPAAM) were synthesized using redox polymerization, followed by N,N-methylenebisacrylamide (BIS) and epichlorohydrin (EPI) were added as chemical crosslinkers. The interaction between membrane compositions has been characterized by FTIR spectroscopy and discussed intensively. The result indicates that HA incorporation in membranes increase the gel fraction, swelling uptake, and the flexibility/elasticity of crosslinked membranes, however it reduced oppositely the mechanical elongation of membranes. PNIPAAm-HA hydrogels responded to both temperature and pH changes and the stimuli-responsiveness was reversible. However, in vitro bioevaluation results revealed that the released ampicillin during the burst release time was sharply influenced and increased with increasing HA contents in membranes; afterwards it became sustainable. Whereas, high HA contents in hydrogels unexpectedly impacted negatively on the cells viability, owing to the viscosity of cell culture media changed. A big resistance was observed against microbial growth of Staphylococcus aureus, Salmonella typhi, and Candida albicans in case of pure PNIPAAm hydrogel membranes without HA or ampicillin. However, HA incorporation or the loaded ampicillin in membranes showed unexpected easily microbial growth. The fast release performance with dual pH-thermo-sensitive hydrogels were suggested as promising materials for quick drug carrier in the biomedical field.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Resinas Acrílicas / Portadores de Fármacos / Ampicilina / Ácido Hialurónico / Antibacterianos Tipo de estudio: Diagnostic_studies Idioma: En Revista: Int J Biol Macromol Año: 2018 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Resinas Acrílicas / Portadores de Fármacos / Ampicilina / Ácido Hialurónico / Antibacterianos Tipo de estudio: Diagnostic_studies Idioma: En Revista: Int J Biol Macromol Año: 2018 Tipo del documento: Article Pais de publicación: Países Bajos