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Italian pool of asbestos workers cohorts: mortality trends of asbestos-related neoplasms after long time since first exposure.
Ferrante, Daniela; Chellini, Elisabetta; Merler, Enzo; Pavone, Venere; Silvestri, Stefano; Miligi, Lucia; Gorini, Giuseppe; Bressan, Vittoria; Girardi, Paolo; Ancona, Laura; Romeo, Elisa; Luberto, Ferdinando; Sala, Orietta; Scarnato, Corrado; Menegozzo, Simona; Oddone, Enrico; Tunesi, Sara; Perticaroli, Patrizia; Pettinari, Aldo; Cuccaro, Francesco; Mattioli, Stefano; Baldassarre, Antonio; Barone-Adesi, Francesco; Cena, Tiziana; Legittimo, Patrizia; Marinaccio, Alessandro; Mirabelli, Dario; Musti, Marina; Pirastu, Roberta; Ranucci, Alessandra; Magnani, Corrado.
Afiliación
  • Ferrante D; Department of Translational Medicine, Unit of Medical Statistics and Epidemiology, University of Eastern Piedmont, and CPO-Piemonte, Novara, Italy.
  • Chellini E; Occupational & Environmental Epidemiology Unit, Cancer Prevention and Research Institute (ISPO), Florence, Italy.
  • Merler E; Local Health Unit, Mesothelioma Register of the Veneto Region, Padua, Italy.
  • Pavone V; Department of Public Health, Prevention and Security Area Work Environments, Local Health Authority, Bologna, Italy.
  • Silvestri S; Cancer Prevention and Research Institute (ISPO), Florence, Italy.
  • Miligi L; Occupational & Environmental Epidemiology Unit, Cancer Prevention and Research Institute (ISPO), Florence, Italy.
  • Gorini G; Occupational & Environmental Epidemiology Unit, Cancer Prevention and Research Institute (ISPO), Florence, Italy.
  • Bressan V; Local Health Unit, Mesothelioma Register of the Veneto Region, Padua, Italy.
  • Girardi P; Local Health Unit, Mesothelioma Register of the Veneto Region, Padua, Italy.
  • Ancona L; Department of Epidemiology, Lazio Regional Health Service, Rome, Italy.
  • Romeo E; Department of Epidemiology, Lazio Regional Health Service, Rome, Italy.
  • Luberto F; Inter-institutional Epidemiology Unit, AUSL Reggio Emilia and Arcispedale Santa Maria Nuova, IRCCS, Reggio Emilia, Italy.
  • Sala O; ARPAE Emilia Romagna, Sezione Provinciale di Reggio Emilia, Reggio Emilia, Italy.
  • Scarnato C; Department of Public Health, Prevention and Security Area Work Environments, Local Health Authority, Bologna, Italy.
  • Menegozzo S; National Cancer Institute IRCCS Fondazione Pascale, Napoli, Italy.
  • Oddone E; Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, Italy.
  • Tunesi S; Department of Translational Medicine, Unit of Medical Statistics and Epidemiology, University of Eastern Piedmont, and CPO-Piemonte, Novara, Italy.
  • Perticaroli P; Unit of Cancer Epidemiology, CPO Piemonte and University of Turin, Turin, Italy.
  • Pettinari A; Prevention Department, ASUR Marche, Senigallia, Italy.
  • Cuccaro F; Prevention Department, ASUR Marche, Senigallia, Italy.
  • Mattioli S; Unit of Epidemiology and Statistics -Local Health Unit of Barletta-Andria-Trani, Barletta, Italy.
  • Baldassarre A; Department Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
  • Barone-Adesi F; Unit of Occupational Medicine, S.Orsola-Malpighi University Hospital, Bari, Italy.
  • Cena T; Interdisciplinary Department of Medicine, Occupational Medicine 'B. Ramazzini, University of Bari, Bari, Italy.
  • Legittimo P; Department of Pharmaceutical Sciences, University of Eastern Piedmont, Novara, Italy.
  • Marinaccio A; Department of Translational Medicine, Unit of Medical Statistics and Epidemiology, University of Eastern Piedmont, and CPO-Piemonte, Novara, Italy.
  • Mirabelli D; Department Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
  • Musti M; Unit of Occupational Medicine, S.Orsola-Malpighi University Hospital, Bari, Italy.
  • Pirastu R; Italian Workers' Compensation Authority (INAIL), Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, Unit of Occupational and Environmental Epidemiology, Italian Mesothelioma Register, Rome, Italy.
  • Ranucci A; Unit of Cancer Epidemiology, CPO Piemonte and University of Turin, Turin, Italy.
  • Magnani C; Interdisciplinary Department of Medicine, Occupational Medicine 'B. Ramazzini, University of Bari, Bari, Italy.
Occup Environ Med ; 74(12): 887-898, 2017 12.
Article en En | MEDLINE | ID: mdl-28775133
OBJECTIVE: Asbestos is a known human carcinogen, with evidence for malignant mesothelioma (MM), cancers of lung, ovary, larynx and possibly other organs. MM rates are predicted to increase with a power of time since first exposure (TSFE), but the possible long-term attenuation of the trend is debated. The asbestos ban enforced in Italy in 1992 gives an opportunity to measure long-term cancer risk in formerly exposed workers. METHODS: Pool of 43 previously studied Italian asbestos cohorts (asbestos cement, rolling stock, shipbuilding), with mortality follow-up updated to 2010. SMRs were computed for the 1970â€"2010 period, for the major causes, with consideration of duration and TSFE, using reference rates by age, sex, region and calendar period. RESULTS: The study included 51 801 subjects (5741 women): 55.9% alive, 42.6% died (cause known for 95%) and 1.5% lost to follow-up. Mortality was significantly increased for all deaths (SMR: men: 1.05, 95% CI 1.03 to 1.06; women: 1.17, 95% CI to 1.12 to 1.22), all malignancies combined (SMR: men: 1.17, 95% CI to 1.14 to 1.20; women: 1.33, 95% CI 1.24 to 1.43), pleural and peritoneal malignancies (SMR: men: 13.28 and 4.77, 95% CI 12.24 to 14.37 and 4.00 to 5.64; women: 28.44 and 6.75, 95% CI 23.83 to 33.69 and 4.70 to 9.39), lung (SMR: men: 1.26, 95% CI 1.21 to 1.31; women: 1.43, 95% CI 1.13 to 1.78) and ovarian cancer (SMR=1.38, 95% CI 1.00 to 1.87) and asbestosis (SMR: men: 300.7, 95% CI 270.7 to 333.2; women: 389.6, 95% CI 290.1 to 512.3). Pleural cancer rate increased during the first 40 years of TSFE and reached a plateau after. DISCUSSION: The study confirmed the increased risk for cancer of the lung, ovary, pleura and peritoneum but not of the larynx and the digestive tract. Pleural cancer mortality reached a plateau at long TSFE, coherently with recent reports.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Neoplasias Peritoneales / Neoplasias Pleurales / Amianto / Exposición Profesional / Neoplasias Pulmonares / Mesotelioma / Enfermedades Profesionales Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Occup Environ Med Asunto de la revista: MEDICINA OCUPACIONAL / SAUDE AMBIENTAL Año: 2017 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Neoplasias Peritoneales / Neoplasias Pleurales / Amianto / Exposición Profesional / Neoplasias Pulmonares / Mesotelioma / Enfermedades Profesionales Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Occup Environ Med Asunto de la revista: MEDICINA OCUPACIONAL / SAUDE AMBIENTAL Año: 2017 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido