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Insights into the role of hepatocyte PPARα activity in response to fasting.
Régnier, Marion; Polizzi, Arnaud; Lippi, Yannick; Fouché, Edwin; Michel, Géraldine; Lukowicz, Céline; Smati, Sarra; Marrot, Alain; Lasserre, Frédéric; Naylies, Claire; Batut, Aurélie; Viars, Fanny; Bertrand-Michel, Justine; Postic, Catherine; Loiseau, Nicolas; Wahli, Walter; Guillou, Hervé; Montagner, Alexandra.
Afiliación
  • Régnier M; Institut National de La Recherche Agronomique (INRA), UMR1331 ToxAlim, Toulouse, France.
  • Polizzi A; Institut National de La Recherche Agronomique (INRA), UMR1331 ToxAlim, Toulouse, France.
  • Lippi Y; Institut National de La Recherche Agronomique (INRA), UMR1331 ToxAlim, Toulouse, France.
  • Fouché E; Institut National de La Recherche Agronomique (INRA), UMR1331 ToxAlim, Toulouse, France.
  • Michel G; Institut National de La Recherche Agronomique (INRA), UMR1331 ToxAlim, Toulouse, France.
  • Lukowicz C; Institut National de La Recherche Agronomique (INRA), UMR1331 ToxAlim, Toulouse, France.
  • Smati S; Institut National de La Recherche Agronomique (INRA), UMR1331 ToxAlim, Toulouse, France; Institut National de La Santé et de La Recherche Médicale (INSERM), UMR1048, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France.
  • Marrot A; Institut National de La Recherche Agronomique (INRA), UMR1331 ToxAlim, Toulouse, France.
  • Lasserre F; Institut National de La Recherche Agronomique (INRA), UMR1331 ToxAlim, Toulouse, France.
  • Naylies C; Institut National de La Recherche Agronomique (INRA), UMR1331 ToxAlim, Toulouse, France.
  • Batut A; Metatoul-Lipidomic Facility, MetaboHUB, Institut National de La Santé et de La Recherche Médicale (INSERM), UMR1048, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France.
  • Viars F; Metatoul-Lipidomic Facility, MetaboHUB, Institut National de La Santé et de La Recherche Médicale (INSERM), UMR1048, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France.
  • Bertrand-Michel J; Metatoul-Lipidomic Facility, MetaboHUB, Institut National de La Santé et de La Recherche Médicale (INSERM), UMR1048, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France.
  • Postic C; Institut National de La Santé et de La Recherche Médicale (INSERM), U1016, Institut Cochin, Paris, France.
  • Loiseau N; Institut National de La Recherche Agronomique (INRA), UMR1331 ToxAlim, Toulouse, France.
  • Wahli W; Institut National de La Recherche Agronomique (INRA), UMR1331 ToxAlim, Toulouse, France; Lee Kong Chian School of Medicine, Nanyang Technological University, Clinical Sciences Building, 11 Mandalay Road, 308232, Singapore; Center for Integrative Genomics, Université de Lausanne, Le Génopode, CH-1015
  • Guillou H; Institut National de La Recherche Agronomique (INRA), UMR1331 ToxAlim, Toulouse, France. Electronic address: herve.guillou@inra.fr.
  • Montagner A; Institut National de La Recherche Agronomique (INRA), UMR1331 ToxAlim, Toulouse, France; Institut National de La Santé et de La Recherche Médicale (INSERM), UMR1048, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France. Electronic address: alexandra.montagner@inserm.fr.
Mol Cell Endocrinol ; 471: 75-88, 2018 08 15.
Article en En | MEDLINE | ID: mdl-28774777
The liver plays a central role in the regulation of fatty acid metabolism. Hepatocytes are highly sensitive to nutrients and hormones that drive extensive transcriptional responses. Nuclear hormone receptors are key transcription factors involved in this process. Among these factors, PPARα is a critical regulator of hepatic lipid catabolism during fasting. This study aimed to analyse the wide array of hepatic PPARα-dependent transcriptional responses during fasting. We compared gene expression in male mice with a hepatocyte specific deletion of PPARα and their wild-type littermates in the fed (ad libitum) and 24-h fasted states. Liver samples were acquired, and transcriptome and lipidome analyses were performed. Our data extended and confirmed the critical role of hepatocyte PPARα as a central for regulator of gene expression during starvation. Interestingly, we identified novel PPARα-sensitive genes, including Cxcl-10, Rab30, and Krt23. We also found that liver phospholipid remodelling was a novel fasting-sensitive pathway regulated by PPARα. These results may contribute to investigations on transcriptional control in hepatic physiology and underscore the clinical relevance of drugs that target PPARα in liver pathologies, such as non-alcoholic fatty liver disease.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ayuno / Hepatocitos / PPAR alfa Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Mol Cell Endocrinol Año: 2018 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Irlanda
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ayuno / Hepatocitos / PPAR alfa Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Mol Cell Endocrinol Año: 2018 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Irlanda