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A Hypothalamic Phosphatase Switch Coordinates Energy Expenditure with Feeding.
Dodd, Garron T; Andrews, Zane B; Simonds, Stephanie E; Michael, Natalie J; DeVeer, Michael; Brüning, Jens C; Spanswick, David; Cowley, Michael A; Tiganis, Tony.
Afiliación
  • Dodd GT; Metabolic Disease and Obesity Program, Biomedicine Discovery Institute, Monash University, Victoria 3800, Australia; Department of Biochemistry and Molecular Biology, Monash University, Victoria 3800, Australia.
  • Andrews ZB; Metabolic Disease and Obesity Program, Biomedicine Discovery Institute, Monash University, Victoria 3800, Australia; Department of Physiology, Monash University, Victoria 3800, Australia.
  • Simonds SE; Metabolic Disease and Obesity Program, Biomedicine Discovery Institute, Monash University, Victoria 3800, Australia; Department of Physiology, Monash University, Victoria 3800, Australia.
  • Michael NJ; Metabolic Disease and Obesity Program, Biomedicine Discovery Institute, Monash University, Victoria 3800, Australia; Department of Physiology, Monash University, Victoria 3800, Australia.
  • DeVeer M; Monash Biomedical Imaging, Monash University, Victoria 3168, Australia.
  • Brüning JC; Max Plank Institute for Metabolism Research, Department of Neuronal Control of Metabolism, Gleueler Str. 50, 50931 Cologne, Germany; Center for Endocrinology, Diabetes, and Preventive Medicine (CEDP), University Hospital Cologne, Kerpener Str. 26, 50924 Cologne, Germany; Excellence Cluster on Cellul
  • Spanswick D; Metabolic Disease and Obesity Program, Biomedicine Discovery Institute, Monash University, Victoria 3800, Australia; Department of Physiology, Monash University, Victoria 3800, Australia.
  • Cowley MA; Metabolic Disease and Obesity Program, Biomedicine Discovery Institute, Monash University, Victoria 3800, Australia; Department of Physiology, Monash University, Victoria 3800, Australia.
  • Tiganis T; Metabolic Disease and Obesity Program, Biomedicine Discovery Institute, Monash University, Victoria 3800, Australia; Department of Biochemistry and Molecular Biology, Monash University, Victoria 3800, Australia. Electronic address: tony.tiganis@monash.edu.
Cell Metab ; 26(2): 375-393.e7, 2017 Aug 01.
Article en En | MEDLINE | ID: mdl-28768176
Beige adipocytes can interconvert between white and brown-like states and switch between energy storage versus expenditure. Here we report that beige adipocyte plasticity is important for feeding-associated changes in energy expenditure and is coordinated by the hypothalamus and the phosphatase TCPTP. A fasting-induced and glucocorticoid-mediated induction of TCPTP, inhibited insulin signaling in AgRP/NPY neurons, repressed the browning of white fat and decreased energy expenditure. Conversely feeding reduced hypothalamic TCPTP, to increase AgRP/NPY neuronal insulin signaling, white adipose tissue browning and energy expenditure. The feeding-induced repression of hypothalamic TCPTP was defective in obesity. Mice lacking TCPTP in AgRP/NPY neurons were resistant to diet-induced obesity and had increased beige fat activity and energy expenditure. The deletion of hypothalamic TCPTP in obesity restored feeding-induced browning and increased energy expenditure to promote weight loss. Our studies define a hypothalamic switch that coordinates energy expenditure with feeding for the maintenance of energy balance.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ingestión de Alimentos / Metabolismo Energético / Proteína Tirosina Fosfatasa no Receptora Tipo 2 / Hipotálamo Tipo de estudio: Health_economic_evaluation Límite: Animals Idioma: En Revista: Cell Metab Asunto de la revista: METABOLISMO Año: 2017 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ingestión de Alimentos / Metabolismo Energético / Proteína Tirosina Fosfatasa no Receptora Tipo 2 / Hipotálamo Tipo de estudio: Health_economic_evaluation Límite: Animals Idioma: En Revista: Cell Metab Asunto de la revista: METABOLISMO Año: 2017 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos