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Mechanosensing in liver regeneration.
Song, Ziwei; Gupta, Kapish; Ng, Inn Chuan; Xing, Jiangwa; Yang, Yi An; Yu, Hanry.
Afiliación
  • Song Z; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Institute of Bioengineering and Nanotechnology, Agency for Science, Technology and Research (A*STAR), Singapore.
  • Gupta K; Mechanobiology Institute, National University of Singapore, Singapore.
  • Ng IC; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
  • Xing J; Institute of Bioengineering and Nanotechnology, Agency for Science, Technology and Research (A*STAR), Singapore.
  • Yang YA; Mechanobiology Institute, National University of Singapore, Singapore.
  • Yu H; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Institute of Bioengineering and Nanotechnology, Agency for Science, Technology and Research (A*STAR), Singapore; Mechanobiology Institute, National University of Singapore, Singapore; BioSyM, Sing
Semin Cell Dev Biol ; 71: 153-167, 2017 11.
Article en En | MEDLINE | ID: mdl-28768152
Liver is highly regenerative as it can restore its function and size even after 70% partial hepatectomy. During liver regeneration, the mechanical and chemical environment of liver is altered with accumulation of various growth factors and remodeling of extracellular environment. Cells can sense the changes in their cellular environment through various chemo and mechanosensors present on their surfaces. These changes are then transduced by initiation of multiple signaling pathways. Traditional view of liver regeneration describes the process as a cascade of chemical signaling pathways. In this review, we describe the role of mechanical forces and mechanosensing in regulating liver regeneration with focus on the role of altered shear and extracellular matrix environment following injury. These mechanosensing mechanisms either generate molecular signals that further activate downstream signaling pathways such as YAP or directly transduce mechanical signals by regulating actomyosin cytoskeleton. These signals travel to the decision center such as nucleus to switch cell fate and activate functions needed in liver regeneration, e.g. proliferation of various hepatic cell types, differentiation of hepatic stem cells, extracellular matrix remodeling and termination signals that regulate the regenerated liver size. Different mechanical and chemical signals coordinate intracellular chemical signaling pathways leading to robust liver regeneration.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Mecanotransducción Celular / Hígado / Regeneración Hepática Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Semin Cell Dev Biol Asunto de la revista: EMBRIOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Singapur Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Mecanotransducción Celular / Hígado / Regeneración Hepática Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Semin Cell Dev Biol Asunto de la revista: EMBRIOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Singapur Pais de publicación: Reino Unido