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Monosialoganglioside 1 may alleviate neurotoxicity induced by propofol combined with remifentanil in neural stem cells.
Lu, Jiang; Yao, Xue-Qin; Luo, Xin; Wang, Yu; Chung, Sookja Kim; Tang, He-Xin; Cheung, Chi Wai; Wang, Xian-Yu; Meng, Chen; Li, Qing.
Afiliación
  • Lu J; Anesthesiology Research Institute of Hubei University of Medicine, Shiyan, Hubei Province, China.
  • Yao XQ; Department of Anesthesiology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei Province, China.
  • Luo X; Anesthesiology Research Institute of Hubei University of Medicine, Shiyan, Hubei Province, China.
  • Wang Y; Department of Anesthesiology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei Province, China.
  • Chung SK; Department of Anesthesiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.
  • Tang HX; Laboratory and Clinical Research Institute for Pain, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.
  • Cheung CW; Department of Anesthesiology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei Province, China.
  • Wang XY; Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.
  • Meng C; Anesthesiology Research Institute of Hubei University of Medicine, Shiyan, Hubei Province, China.
  • Li Q; Anesthesiology Research Institute of Hubei University of Medicine, Shiyan, Hubei Province, China.
Neural Regen Res ; 12(6): 945-952, 2017 Jun.
Article en En | MEDLINE | ID: mdl-28761428
Monosialoganglioside 1 (GM1) is the main ganglioside subtype and has neuroprotective properties in the central nervous system. In this study, we aimed to determine whether GM1 alleviates neurotoxicity induced by moderate and high concentrations of propofol combined with remifentanil in the immature central nervous system. Hippocampal neural stem cells were isolated from newborn Sprague-Dawley rats and treated with remifentanil (5, 10, 20 ng/mL) and propofol (1.0, 2.5, 5.0 µg/mL), and/or GM1 (12.5, 25, 50 µg/mL). GM1 reversed combined propofol and remifentanil-induced decreases in the percentage of 5-bromodeoxyuridine(+) cells and also reversed the increase in apoptotic cell percentage during neural stem cell proliferation and differentiation. However, GM1 with combined propofol and remifentanil did not affect ß-tubulin(+) or glial fibrillary acidic protein(+) cell percentage during neural stem cell differentiation. In conclusion, we show that GM1 alleviates the damaging effects of propofol combined with remifentanil at moderate and high exposure concentrations in neural stem cells in vitro, and exerts protective effects on the immature central nervous system.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Neural Regen Res Año: 2017 Tipo del documento: Article País de afiliación: China Pais de publicación: India
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Neural Regen Res Año: 2017 Tipo del documento: Article País de afiliación: China Pais de publicación: India