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Discovery of a para-Acetoxy-benzyl Ester Prodrug of a Hydroxamate-Based Glutamate Carboxypeptidase II Inhibitor as Oral Therapy for Neuropathic Pain.
Rais, Rana; Vávra, Jan; Tichý, Tomás; Dash, Ranjeet P; Gadiano, Alexandra J; Tenora, Lukás; Monincová, Lenka; Barinka, Cyril; Alt, Jesse; Zimmermann, Sarah C; Slusher, C Ethan; Wu, Ying; Wozniak, Krystyna; Majer, Pavel; Tsukamoto, Takashi; Slusher, Barbara S.
Afiliación
  • Vávra J; Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, vvi , 166 10 Prague, Czech Republic.
  • Tichý T; Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, vvi , 166 10 Prague, Czech Republic.
  • Tenora L; Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, vvi , 166 10 Prague, Czech Republic.
  • Monincová L; Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, vvi , 166 10 Prague, Czech Republic.
  • Barinka C; Institute of Biotechnology, Academy of Sciences of the Czech Republic, vvi , 166 10 Prague, Czech Republic.
  • Majer P; Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, vvi , 166 10 Prague, Czech Republic.
J Med Chem ; 60(18): 7799-7809, 2017 09 28.
Article en En | MEDLINE | ID: mdl-28759215
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Profármacos / Glutamato Carboxipeptidasa II / Inhibidores Enzimáticos / Ácidos Hidroxámicos / Analgésicos / Neuralgia Límite: Animals / Humans / Male Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Profármacos / Glutamato Carboxipeptidasa II / Inhibidores Enzimáticos / Ácidos Hidroxámicos / Analgésicos / Neuralgia Límite: Animals / Humans / Male Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos