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Gold-Embedded Hollow Silica Nanogolf Balls for Imaging and Photothermal Therapy.
Janetanakit, Woraphong; Wang, Liping; Santacruz-Gomez, Karla; Landon, Preston B; Sud, Paul L; Patel, Nirav; Jang, Grace; Jain, Malvika; Yepremyan, Alice; Kazmi, Sami A; Ban, Deependra K; Zhang, Feng; Lal, Ratnesh.
Afiliación
  • Wang L; School of Biomedical Engineering, Shanghai Jiaotong University , Shanghai 200241, P. R. China.
  • Santacruz-Gomez K; Department of Physics, University of Sonora , Hermosillo 83000, México.
  • Zhang F; Agricultural Nanocenter, School of Life Sciences, Inner Mongolia Agricultural University , Inner Mongolia, Hohhot 010018, P. R. China.
  • Lal R; Department of Biomedical Engineering, School of Basic Medical Sciences, Guangzhou Medical University , Guangzhou 511436, P. R. China.
ACS Appl Mater Interfaces ; 9(33): 27533-27543, 2017 Aug 23.
Article en En | MEDLINE | ID: mdl-28752765
Hybrid nanocarriers with multifunctional properties have wide therapeutic and diagnostic applications. We have constructed hollow silica nanogolf balls (HGBs) and gold-embedded hollow silica nanogolf balls (Au@SiO2 HGBs) using the layer-by-layer approach on a symmetric polystyrene (PS) Janus template; the template consists of smaller PS spheres attached to an oppositely charged large PS core. ζ Potential measurement supports the electric force-based template-assisted synthesis mechanism. Electron microscopy, UV-vis, and near-infrared (NIR) spectroscopy show that HGBs or Au@SiO2 HGBs are composed of a porous silica shell with an optional dense layer of gold nanoparticles embedded in the silica shell. To visualize their cellular uptake and imaging potential, Au@SiO2 HGBs were loaded with quantum dots (QDs). Confocal fluorescent microscopy and atomic force microscopy imaging show reliable endocytosis of QD-loaded Au@SiO2 HGBs in adherent HeLa cells and circulating red blood cells (RBCs). Surface-enhanced Raman spectroscopy of Au@SiO2 HGBs in RBC cells show enhanced intensity of the Raman signal specific to the RBCs' membrane specific spectral markers. Au@SiO2 HGBs show localized surface plasmon resonance and heat-induced HeLa cell death in the NIR range. These hybrid golf ball nanocarriers would have broad applications in personalized nanomedicine ranging from in vivo imaging to photothermal therapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oro Límite: Humans Idioma: En Revista: ACS Appl Mater Interfaces Asunto de la revista: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oro Límite: Humans Idioma: En Revista: ACS Appl Mater Interfaces Asunto de la revista: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos