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Protective effects of 4-methylcoumarins and related compounds as radical scavengers and chain-breaking antioxidants.
Kancheva, Vessela D; Slavova-Kazakova, Adriana K; Angelova, Silvia E; Singh, Suraj K; Malhotra, Shashwat; Singh, Brajendra K; Saso, Luciano; Prasad, Ashok K; Parmar, Virinder S.
Afiliación
  • Kancheva VD; Lipid Chemistry and Theoretical Chemistry Departments, Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria. Electronic address: vessy.kancheva@abv.bg.
  • Slavova-Kazakova AK; Lipid Chemistry and Theoretical Chemistry Departments, Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.
  • Angelova SE; Lipid Chemistry and Theoretical Chemistry Departments, Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.
  • Singh SK; Bioorganic Laboratory, Department of Chemistry, University of Delhi, Delhi, 110 007, India.
  • Malhotra S; Bioorganic Laboratory, Department of Chemistry, University of Delhi, Delhi, 110 007, India.
  • Singh BK; Bioorganic Laboratory, Department of Chemistry, University of Delhi, Delhi, 110 007, India.
  • Saso L; Department of Human Physiology and Pharmacology "Vitorio Erspamer", University of Rome "La Sapienza", 00185 Rome, Italy.
  • Prasad AK; Bioorganic Laboratory, Department of Chemistry, University of Delhi, Delhi, 110 007, India.
  • Parmar VS; Bioorganic Laboratory, Department of Chemistry, University of Delhi, Delhi, 110 007, India; Institute of Advanced Sciences, 86-410 Faunce Corner Mall Road, Dartmouth, MA 02747, USA.
Biochimie ; 140: 133-145, 2017 Sep.
Article en En | MEDLINE | ID: mdl-28751215
The aim of this study is to determine, and to compare the protective effects of eight 4-methylcoumarins and four related compounds as radical scavengers and chain-breaking antioxidants. The main kinetic parameters of their radical scavenging activity (as % RSA, stoichiometry, n, and rate constants of reaction with DPPH radical, kRSA) and of chain breaking antioxidant activity (as antioxidant efficiency, PF and reactivity, ID), have been determined and discussed. The RSA study has been conducted at physiological temperature (37 °Ð¡) towards DPPH radical and the tested compounds are separated into three main groups: with strong activity (% RSA > 40%); with moderate activity (20% < % RSA > 40%) and with weak activity (% RSA < 20%). Chain-breaking antioxidant activities of the studied compounds have been evaluated during bulk phase lipid (triacylglycerols of sunflower oil, TGSO) autoxidation at 80 °C. All results obtained are compared with those for standard and known inhibitors of oxidation processes, e.g. caffeic and p-coumaric acids, α-tocopherol and butylated hydroxytoluene (BHT). On the basis of a comparative analysis with standard antioxidants, the differences in the radical scavenging and antioxidant abilities of the studied compounds have been discussed and reaction mechanisms proposed. All structures are optimized at UB3LYP/6-31 + G(d,p) level in gas phase and in acetone solution to study the solvation effects.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Depuradores de Radicales Libres / Cumarinas Idioma: En Revista: Biochimie Año: 2017 Tipo del documento: Article Pais de publicación: Francia
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Depuradores de Radicales Libres / Cumarinas Idioma: En Revista: Biochimie Año: 2017 Tipo del documento: Article Pais de publicación: Francia