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Fertility preservation issues in pediatric hematopoietic stem cell transplantation: practical approaches from the consensus of the Pediatric Diseases Working Party of the EBMT and the International BFM Study Group.
Balduzzi, A; Dalle, J-H; Jahnukainen, K; von Wolff, M; Lucchini, G; Ifversen, M; Macklon, K T; Poirot, C; Diesch, T; Jarisch, A; Bresters, D; Yaniv, I; Gibson, B; Willasch, A M; Fadini, R; Ferrari, L; Lawitschka, A; Ahler, A; Sänger, N; Corbacioglu, S; Ansari, M; Moffat, R; Dalissier, A; Beohou, E; Sedlacek, P; Lankester, A; De Heredia Rubio, C D; Vettenranta, K; Wachowiak, J; Yesilipek, A; Trigoso, E; Klingebiel, T; Peters, C; Bader, P.
Afiliación
  • Balduzzi A; Clinica Pediatrica, Università degli Studi di Milano Bicocca, Fondazione Monza e Brianza per il Bambino e la sua Mamma, Ospedale San Gerardo, Monza, Italy.
  • Dalle JH; Hemato-Immunology Department, Robert-Debre Hospital, APHP and Paris-Diderot University, Paris, France.
  • Jahnukainen K; Division of Hematology-Oncology and Stem Cell Transplantation, Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  • von Wolff M; Division of Reproductive Medicine and Endocrinology, Department of Obstetrics and Gynecology, Inselspital Bern, University Hospital, Bern, Switzerland.
  • Lucchini G; Bone Marrow Transplant Department, Great Ormond Street Hospital, London, UK.
  • Ifversen M; Department of Pediatric and Adolescent Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
  • Macklon KT; The Fertility Clinic, Copenhagen University Hospital, Copenhagen, Denmark.
  • Poirot C; Adolescent and Young Adult Hematology Unit, Saint Louis Hospital, Assistance Publique-Hôpitaux de Paris, University Pierre et Marie Curie, Paris, France.
  • Diesch T; Department of Pediatric Hematology/Oncology, University Children's Hospital of Basel, Basel, Switzerland.
  • Jarisch A; Division for Stem Cell Transplantation and Immunology, Department for Children and Adolescents, University Hospital, Goethe University Frankfurt am Main, Frankfurt, Germany.
  • Bresters D; Willem-Alexander Children's Hospital, Leiden University Medical Center, Leiden, The Netherlands.
  • Yaniv I; Pediatric Hematology Oncology, Schneider Children's Medical Center of Israel, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Gibson B; Department of Paediatric Haematology, Royal Hospital for Children, Scotland, UK.
  • Willasch AM; Division for Stem Cell Transplantation and Immunology, Department for Children and Adolescents, University Hospital, Goethe University Frankfurt am Main, Frankfurt, Germany.
  • Fadini R; Centro di Medicina della Riproduzione Biogenesi, Istituti Clinici Zucchi, Monza, Italy.
  • Ferrari L; Department of Gynecology and Obstetrics, Ospedale San Gerardo di Monza, Monza, Italy.
  • Lawitschka A; St Anna Children's Hospital, UKKJ, MUW, Vienna, Austria.
  • Ahler A; Division of Reproductive Medicine and Endocrinology, Department of Obstetrics and Gynaecology, University Hospital, Basel, Switzerland.
  • Sänger N; Division of Reproductive Medicine, Endocrinology and Infertility, Department of Obstetrics and Gynecology, University Hospital, JW Goethe University, Frankfurt, Germany.
  • Corbacioglu S; Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, University Hospital, University of Regensburg, Regensburg, Germany.
  • Ansari M; Department of Pediatrics, Hémato-Oncologie Pédiatrique, CANSEARCH Research Laboratory, Université de Médecine de Genève, Geneva, Switzerland.
  • Moffat R; Division of Reproductive Medicine and Endocrinology, Department of Obstetrics and Gynaecology, University Hospital, Basel, Switzerland.
  • Dalissier A; EBMT Paris Office, Hospital Saint Antoine, Paris, France.
  • Beohou E; EBMT Paris Office, Hospital Saint Antoine, Paris, France.
  • Sedlacek P; Department of Pediatric Hematology and Oncology, University Hospital Motol, Prague, Czech Republic.
  • Lankester A; Willem-Alexander Children's Hospital, Leiden University Medical Center, Leiden, The Netherlands.
  • De Heredia Rubio CD; Pediatric Oncology and Hematology Department, Hospital Universitario Vall d'Hebron, Barcelona, Spain.
  • Vettenranta K; Division of Hematology-Oncology and Stem Cell Transplantation, Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  • Wachowiak J; Department of Pediatric Oncology, Hematology and Transplantology, University of Medical Sciences, Poznan, Poland.
  • Yesilipek A; Bahcesehir University School of Medicine, Department of Pediatrics, Pediatric Stem Cell Transplantation Unit, Istanbul, Turkey.
  • Trigoso E; Paediatric Oncology Unit, Paediatric Transplant Unit, Polytechnic and University Hospital 'LA FE', Valencia, Spain.
  • Klingebiel T; Division for Stem Cell Transplantation and Immunology, Department for Children and Adolescents, University Hospital, Goethe University Frankfurt am Main, Frankfurt, Germany.
  • Peters C; St Anna Children's Hospital, UKKJ, MUW, Vienna, Austria.
  • Bader P; Division for Stem Cell Transplantation and Immunology, Department for Children and Adolescents, University Hospital, Goethe University Frankfurt am Main, Frankfurt, Germany.
Bone Marrow Transplant ; 52(10): 1406-1415, 2017 Oct.
Article en En | MEDLINE | ID: mdl-28737775
Fertility preservation is an urgent challenge in the transplant setting. A panel of transplanters and fertility specialists within the Pediatric Diseases Working Party of the European Society for Blood and Marrow Transplantation (EBMT) and the International BFM Study Group provides specific guidelines. Patients and families should be informed of possible gender- and age-specific cryopreservation strategies that should be tailored according to the underlying disease, clinical condition and previous exposure to chemotherapy. Semen collection should be routinely offered to all postpubertal boys at the diagnosis of any disease requiring therapy that could potentially impair fertility. Testicular tissue collection might be offered to postpubertal boys; nevertheless, its use has been unsuccessful to date. Oocyte collection after hormonal hyperstimulation should be offered to postpubertal girls facing gonadotoxic therapies that could be delayed for the 2 weeks required for the procedure. Ovarian tissue collection could be offered to pre-/post-pubertal girls. Pregnancies have been reported after postpubertal ovarian tissue reimplantation; however, to date, no pregnancy has been reported after the reimplantation of prepubertal ovarian tissue or in vitro maturation of pre-/post-pubertal ovarian tissue. Possible future advances in reproductive medicine could change this scenario. Health authorities should prioritize fertility preservation projects in pediatric transplantation to improve patient care and quality of life.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ovario / Testículo / Criopreservación / Trasplante de Células Madre Hematopoyéticas / Consenso / Preservación de la Fertilidad / Antineoplásicos Tipo de estudio: Clinical_trials / Guideline Aspecto: Patient_preference Límite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: Bone Marrow Transplant Asunto de la revista: TRANSPLANTE Año: 2017 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ovario / Testículo / Criopreservación / Trasplante de Células Madre Hematopoyéticas / Consenso / Preservación de la Fertilidad / Antineoplásicos Tipo de estudio: Clinical_trials / Guideline Aspecto: Patient_preference Límite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: Bone Marrow Transplant Asunto de la revista: TRANSPLANTE Año: 2017 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido