Your browser doesn't support javascript.
loading
Sensitive and non-invasive method for the in vivo analysis of membrane permeability in small animals.
Fernandez-Carrera, Andrea; Vigo, Eva; Regueiro-Rodríguez, Carla; González-Fernández, África; Olivieri, David; Aroeira, Luiz S.
Afiliación
  • Fernandez-Carrera A; Immunology, Biomedical Research Center (CINBIO) (Centro Singular de Investigación de Galicia 2016-2019) and Galicia-Sur Health Research Institute (IIS-GS), University Campus, University of Vigo, Vigo, Spain.
  • Vigo E; Endocrinology Laboratory, Biomedical Research Center (CINBIO) (Centro Singular de Investigación de Galicia 2016-2019) and Galicia-Sur Health Research Institute (IIS-GS), University Campus, University of Vigo, Vigo, Spain.
  • Regueiro-Rodríguez C; Immunology, Biomedical Research Center (CINBIO) (Centro Singular de Investigación de Galicia 2016-2019) and Galicia-Sur Health Research Institute (IIS-GS), University Campus, University of Vigo, Vigo, Spain.
  • González-Fernández Á; Immunology, Biomedical Research Center (CINBIO) (Centro Singular de Investigación de Galicia 2016-2019) and Galicia-Sur Health Research Institute (IIS-GS), University Campus, University of Vigo, Vigo, Spain.
  • Olivieri D; Department of Computer Science, University of Vigo, Ourense, Spain.
  • Aroeira LS; Immunology, Biomedical Research Center (CINBIO) (Centro Singular de Investigación de Galicia 2016-2019) and Galicia-Sur Health Research Institute (IIS-GS), University Campus, University of Vigo, Vigo, Spain.
Lab Invest ; 97(9): 1114-1120, 2017 09.
Article en En | MEDLINE | ID: mdl-28737767
Tissue membranes are boundaries that isolate organs or cavities in the body. These semi-permeable membranes are responsible for passive protection that acts through the regulation of nutrient absorption, secretion and filtration of small molecules. These functions could be altered as a consequence of inflammation or trauma, which in turn could lead to changes in permeability, allowing the entrance of toxins, antigens, proteins or facilitating the spread of tumors. Membrane permeability therefore plays an important role in numerous diseases. However, current experimental techniques that are available to quantify membrane permeability in small animals have limited precision and temporal specificity. Improvements in such measurements would lead to a deeper understanding of disease pathogenesis and this may accelerate the development of specific therapies. The study reported here concerns the efficacy of a novel, non-invasive imaging analysis-based measurement method that significantly improves the quantification of tissue membrane permeability in small animals, while at the same time mitigating the adverse effects experienced by the animals under study.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Peritoneo / Permeabilidad de la Membrana Celular / Modelos Animales de Enfermedad / Imagen Óptica Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Revista: Lab Invest Año: 2017 Tipo del documento: Article País de afiliación: España Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Peritoneo / Permeabilidad de la Membrana Celular / Modelos Animales de Enfermedad / Imagen Óptica Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Revista: Lab Invest Año: 2017 Tipo del documento: Article País de afiliación: España Pais de publicación: Estados Unidos