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Locally Transplanted CD34+ Bone Marrow-Derived Cells Contribute to Vascular Healing After Vascular Injury.
Ananthaseshan, S; Grudzinska, M K; Bojakowski, K; Kurzejamska, E; Gaciong, Z; Söderberg-Nauclér, C; Religa, P.
Afiliación
  • Ananthaseshan S; Experimental Cardiovascular Research Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.
  • Grudzinska MK; Experimental Cardiovascular Research Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.
  • Bojakowski K; Department of Medicine, Warsaw Medical University, Warsaw, Poland.
  • Kurzejamska E; Experimental Cardiovascular Research Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.
  • Gaciong Z; Department of Medicine, Warsaw Medical University, Warsaw, Poland.
  • Söderberg-Nauclér C; Experimental Cardiovascular Research Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.
  • Religa P; Experimental Cardiovascular Research Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden; Department of Medicine, Warsaw Medical University, Warsaw, Poland. Electronic address: Piotr.religa@ki.se.
Transplant Proc ; 49(6): 1467-1476, 2017.
Article en En | MEDLINE | ID: mdl-28736025
INTRODUCTION: Vascular progenitor cells contribute to repair of injured vasculature. In this study, we aimed to investigate the role of bone marrow-derived cells in the intimal formation after arterial injury. METHODS AND RESULTS: Balloon injury of the femoral artery of wild-type mice was followed by local delivery of bone marrow-derived cells from GFP transgenic mice. The arteries were collected 1, 4, 7, and 14 days after injury and studied for morphology, localization, and phenotypes of delivered cells. Bone marrow-derived cells were present in the intima only at the early stages of arterial injury and expressed endothelial progenitor cell markers (CD31, CD34, and VEGFR-2). In the areas where intima was thicker, bone marrow-derived cells differentiated to intimal smooth muscle cells but they did not fuse with intimal cells. Delivery of CD34+ cells contributed to a 1.5-fold inhibition of intimal hyperplasia. CONCLUSION: Bone marrow-derived endothelial cells differentiated but did not fuse with vascular smooth muscle cells at the early stages of intimal formation and contributed to intimal hyperplasia.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células de la Médula Ósea / Trasplante de Médula Ósea / Antígenos CD34 / Lesiones del Sistema Vascular Límite: Animals Idioma: En Revista: Transplant Proc Año: 2017 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células de la Médula Ósea / Trasplante de Médula Ósea / Antígenos CD34 / Lesiones del Sistema Vascular Límite: Animals Idioma: En Revista: Transplant Proc Año: 2017 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Estados Unidos