Myo-inositol and selenium reduce the risk of developing overt hypothyroidism in patients with autoimmune thyroiditis.

Ferrari, S M; Fallahi, P; Di Bari, F; Vita, R; Benvenga, S; Antonelli, A

Ferrari, S M; Fallahi, P; Di Bari, F; Vita, R; Benvenga, S; Antonelli, A.

Afiliación

Ferrari SM; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy. alessandro.antonelli@med.unipi.it.

Eur Rev Med Pharmacol Sci ; 21(2 Suppl): 36-42, 2017 06.

Article en En | MEDLINE | ID: mdl-28724175

RESUMEN

OBJECTIVE: The beneficial effects obtained by myo-inositol in association with seleno-methionine in patients affected by subclinical hypothyroidism have been recently demonstrated. Here, we evaluate the immune-modulating effect of myo-inositol in association with seleno-methionine in patients with euthyroid autoimmune thyroiditis (AT). PATIENTS AND METHODS: Twenty-one consecutive Caucasian patients with newly diagnosed euthyroid chronic AT were evaluated. All subjects were treated with myo-inositol in association with selenium (600 mg/83 mg) tablets, twice per day, for six months. A complete thyroid assessment was done before the treatment, and after six months. RESULTS: After the treatment thyroid-stimulating hormone (TSH) levels significantly declined with respect to basal values, overall in patients with an initial TSH value in the high normal range (2.1

Asunto(s)

Hipotiroidismo/complicaciones; Hipotiroidismo/prevención & control; Inositol/uso terapéutico; Metionina/análogos & derivados; Compuestos de Organoselenio/uso terapéutico; Selenio/uso terapéutico; Tiroiditis Autoinmune/complicaciones; Autoanticuerpos/sangre; Quimiocina CXCL10/sangre; Progresión de la Enfermedad; Quimioterapia Combinada; Femenino; Humanos; Hipotiroidismo/sangre; Masculino; Metionina/uso terapéutico; Persona de Mediana Edad; Glándula Tiroides/irrigación sanguínea; Glándula Tiroides/diagnóstico por imagen; Tiroiditis Autoinmune/sangre; Tiroiditis Autoinmune/tratamiento farmacológico; Tirotropina/sangre

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Selenio / Tiroiditis Autoinmune / Compuestos de Organoselenio / Hipotiroidismo / Inositol / Metionina Tipo de estudio: Etiology_studies / Risk_factors_studies Aspecto: Patient_preference Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Eur Rev Med Pharmacol Sci Asunto de la revista: FARMACOLOGIA / TOXICOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Italia

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