Your browser doesn't support javascript.
loading
Effects of Eplerenone on Resistance to Antihypertensive Medication in Patients with Primary or Secondary Hyperaldosteronism.
Spence, J David; Bogiatzi, Chrysi; Kuk, Mariya; Dresser, George K; Hackam, Daniel G.
Afiliación
  • Spence JD; Stroke Prevention & Atherosclerosis Research Centre, Robarts Research Institute, Western University, London, Canada.
  • Bogiatzi C; Stroke Prevention & Atherosclerosis Research Centre, Robarts Research Institute, Western University, London, Canada.
  • Kuk M; McMaster University, Hamilton, Canada.
  • Dresser GK; Stroke Prevention & Atherosclerosis Research Centre, Robarts Research Institute, Western University, London, Canada.
  • Hackam DG; University of Ottawa, Ottawa, Canada.
J Transl Int Med ; 5(2): 93-99, 2017 Jun.
Article en En | MEDLINE | ID: mdl-28721341
BACKGROUND AND OBJECTIVES: Resistant hypertension is an important problem; nearly half of diagnosed hypertensives are not controlled to target blood pressure levels, and approximately 90% of strokes occur among patients with resistant hypertension. Primary aldosteronism accounts for approximately 20% of resistant hypertension, but the role of secondary hyperaldosteronism in resistant hypertension is seldom considered. We assessed the effects of eplerenone in patients with hypertension and either primary or secondary hyperaldosteronism. METHODS: Patients with a history of resistant hypertension and a supine plasma aldosterone level ≥ 360 pmol/L were randomized to eplerenone versus placebo in a fully blinded study for one year. A medication intensity score was developed to assess the resistance of hypertension to medication (blood pressure × medication intensity). We assessed the effects of eplerenone on blood pressure and on resistance to concomitant medication. RESULTS: Final results were available in 37 patients (19 on eplerenone and 18 on placebo). Resistance to medication, as assessed by the intensity of concomitant medication required to maintain blood pressure control, was markedly reduced by eplerenone: medication intensity scores declined by -0.50 ± 1.04 (SD) on placebo versus -2.11 ± 1.45 with eplerenone (P = 0.0001), the Systolic Resistance Score declined by -80.00 ± 122.93 on placebo versus -334.05 ± 21.73 on eplerenone (P = 0.0001), and the Diastolic Resistance Score increased by 1.28 ± 31.65 on placebo and declined by -40.74 ± 57.08 on eplerenone (P = 0.009). CONCLUSIONS: Eplerenone significantly reduced resistance to concomitant antihypertensive medication in both primary and secondary hyperaldosteronism.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Clinical_trials Idioma: En Revista: J Transl Int Med Año: 2017 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Polonia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Clinical_trials Idioma: En Revista: J Transl Int Med Año: 2017 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Polonia