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An overview of in vitro dissolution/release methods for novel mucosal drug delivery systems.
Jug, Mario; Hafner, Anita; Lovric, Jasmina; Kregar, Maja Lusina; Pepic, Ivan; Vanic, Zeljka; Cetina-Cizmek, Biserka; Filipovic-Grcic, Jelena.
Afiliación
  • Jug M; University of Zagreb, Faculty of Pharmacy and Biochemistry, Department of Pharmaceutical Technology, A. Kovacica 1, 10 000 Zagreb, Croatia. Electronic address: mjug@pharma.hr.
  • Hafner A; University of Zagreb, Faculty of Pharmacy and Biochemistry, Department of Pharmaceutical Technology, A. Kovacica 1, 10 000 Zagreb, Croatia.
  • Lovric J; University of Zagreb, Faculty of Pharmacy and Biochemistry, Department of Pharmaceutical Technology, A. Kovacica 1, 10 000 Zagreb, Croatia.
  • Kregar ML; PLIVA Croatia Ltd., TEVA Group Member, Prilaz Baruna Filipovica 25, 10000 Zagreb, Croatia.
  • Pepic I; University of Zagreb, Faculty of Pharmacy and Biochemistry, Department of Pharmaceutical Technology, A. Kovacica 1, 10 000 Zagreb, Croatia.
  • Vanic Z; University of Zagreb, Faculty of Pharmacy and Biochemistry, Department of Pharmaceutical Technology, A. Kovacica 1, 10 000 Zagreb, Croatia.
  • Cetina-Cizmek B; PLIVA Croatia Ltd., TEVA Group Member, Prilaz Baruna Filipovica 25, 10000 Zagreb, Croatia.
  • Filipovic-Grcic J; University of Zagreb, Faculty of Pharmacy and Biochemistry, Department of Pharmaceutical Technology, A. Kovacica 1, 10 000 Zagreb, Croatia.
J Pharm Biomed Anal ; 147: 350-366, 2018 Jan 05.
Article en En | MEDLINE | ID: mdl-28720350
In vitro dissolution/release tests are an important tool in the drug product development phase as well as in its quality control and the regulatory approval process. Mucosal drug delivery systems are aimed to provide both local and systemic drug action via mucosal surfaces of the body and exhibit significant differences in formulation design, as well as in their physicochemical and release characteristics. Therefore it is not possible to devise a single test system which would be suitable for release testing of such complex dosage forms. This article is aimed to provide a comprehensive review of both compendial and noncompendial methods used for in vitro dissolution/release testing of novel mucosal drug delivery systems aimed for ocular, nasal, oromucosal, vaginal and rectal administration.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Preparaciones Farmacéuticas / Química Farmacéutica / Sistemas de Liberación de Medicamentos / Liberación de Fármacos / Membrana Mucosa Límite: Animals / Humans Idioma: En Revista: J Pharm Biomed Anal Año: 2018 Tipo del documento: Article Pais de publicación: Reino Unido
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Preparaciones Farmacéuticas / Química Farmacéutica / Sistemas de Liberación de Medicamentos / Liberación de Fármacos / Membrana Mucosa Límite: Animals / Humans Idioma: En Revista: J Pharm Biomed Anal Año: 2018 Tipo del documento: Article Pais de publicación: Reino Unido