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Flow-mediated dilatation test using optoacoustic imaging: a proof-of-concept.
Karlas, Angelos; Reber, Josefine; Diot, Gael; Bozhko, Dmitry; Anastasopoulou, Maria; Ibrahim, Tareq; Schwaiger, Markus; Hyafil, Fabien; Ntziachristos, Vasilis.
Afiliación
  • Karlas A; HelmholtzZentrum München, Institute for Biological and Medical Imaging, 85764 Neuherberg, Germany.
  • Reber J; Munich School of Bioengineering, Technische Universität München (TUM), 81675 Munich, Germany.
  • Diot G; Klinikum Rechts der Isar, Department of Cardiology, Ismaningerstrasse 22, 81675 Munich, Germany.
  • Bozhko D; HelmholtzZentrum München, Institute for Biological and Medical Imaging, 85764 Neuherberg, Germany.
  • Anastasopoulou M; Munich School of Bioengineering, Technische Universität München (TUM), 81675 Munich, Germany.
  • Ibrahim T; HelmholtzZentrum München, Institute for Biological and Medical Imaging, 85764 Neuherberg, Germany.
  • Schwaiger M; HelmholtzZentrum München, Institute for Biological and Medical Imaging, 85764 Neuherberg, Germany.
  • Hyafil F; Klinikum Rechts der Isar, Department of Cardiology, Ismaningerstrasse 22, 81675 Munich, Germany.
  • Ntziachristos V; Klinikum Rechts der Isar, Department of Nuclear Medicine, Ismaningerstrasse 22, 81675 Munich, Germany.
Biomed Opt Express ; 8(7): 3395-3403, 2017 Jul 01.
Article en En | MEDLINE | ID: mdl-28717575
Label-free multispectral optoacoustic tomography (MSOT) has recently shown superior performance in visualizing the morphology of human vasculature, especially of smaller vessels, compared to ultrasonography. Herein, we extend these observations towards MSOT interrogation of macrovascular endothelial function. We employed a real-time handheld MSOT scanner to assess flow-mediated dilatation (FMD), a technique used to characterize endothelial function. A data processing scheme was developed to quantify the dimensions and diameter changes of arteries in humans and determine wall distensibility parameters. By enabling high-resolution delineation of the blood-vessel wall in a cross-sectional fashion, the findings suggest MSOT as a capable alternative to ultrasonography for clinical FMD measurements.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biomed Opt Express Año: 2017 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biomed Opt Express Año: 2017 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos