miR-380-5p-mediated repression of TEP1 and TSPYL5 interferes with telomerase activity and favours the emergence of an "ALT-like" phenotype in diffuse malignant peritoneal mesothelioma cells.

Cimino-Reale, Graziella; Gandellini, Paolo; Santambrogio, Francesca; Recagni, Marta; Zaffaroni, Nadia; Folini, Marco

Cimino-Reale, Graziella; Gandellini, Paolo; Santambrogio, Francesca; Recagni, Marta; Zaffaroni, Nadia; Folini, Marco.

Afiliación

Cimino-Reale G; Molecular Pharmacology Unit, Department of Applied Research and Technological Development, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Amadeo, 42 - 20133, Milano, Italy.
Gandellini P; Molecular Pharmacology Unit, Department of Applied Research and Technological Development, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Amadeo, 42 - 20133, Milano, Italy.
Santambrogio F; Molecular Pharmacology Unit, Department of Applied Research and Technological Development, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Amadeo, 42 - 20133, Milano, Italy.
Recagni M; Molecular Pharmacology Unit, Department of Applied Research and Technological Development, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Amadeo, 42 - 20133, Milano, Italy.
Zaffaroni N; Molecular Pharmacology Unit, Department of Applied Research and Technological Development, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Amadeo, 42 - 20133, Milano, Italy.
Folini M; Molecular Pharmacology Unit, Department of Applied Research and Technological Development, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Amadeo, 42 - 20133, Milano, Italy. marco.folini@istitutotumori.mi.it.

J Hematol Oncol ; 10(1): 140, 2017 07 17.

Article en En | MEDLINE | ID: mdl-28716051

Asunto(s)

Proteínas Portadoras/genética; Neoplasias Pulmonares/genética; Mesotelioma/genética; MicroARNs/metabolismo; Proteínas Nucleares/genética; Telomerasa/genética; Proteínas Portadoras/metabolismo; Proliferación Celular; Humanos; Neoplasias Pulmonares/metabolismo; Mesotelioma/metabolismo; Mesotelioma Maligno; Proteínas Nucleares/metabolismo; Fenotipo; Pronóstico; Proteínas de Unión al ARN; Transfección

Palabras clave

Alternative lengthening of telomeres; Diffuse malignant peritoneal mesothelioma; Telomerase associated protein 1; Telomere maintenance mechanisms; Testis-specific protein, Y-encoded-like 5; miRNA

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Nucleares / Proteínas Portadoras / Telomerasa / MicroARNs / Neoplasias Pulmonares / Mesotelioma Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Hematol Oncol Asunto de la revista: HEMATOLOGIA / NEOPLASIAS Año: 2017 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido

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