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Genomic Influences on Susceptibility and Severity of Rheumatoid Arthritis.
Knevel, Rachel; Huizinga, Tom W J; Kurreeman, Fina.
Afiliación
  • Knevel R; Brigham and Women's Hospital, Division of Genetics, Raychaudhuri Lab, 77 Avenue Louis Pasteur, 2th Floor, Room 255, Boston, MA 02115, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA; Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands; The Broad Institute, 415 Main Street, Cambridge, MA 02142, USA. Electronic address: rknevel@bwh.harvard.edu.
  • Huizinga TWJ; Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.
  • Kurreeman F; Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.
Rheum Dis Clin North Am ; 43(3): 347-361, 2017 08.
Article en En | MEDLINE | ID: mdl-28711138
Genetics in rheumatoid arthritis (RA) has moved from the finding of HLA-shared epitope decades ago toward the understanding of the role of HLA in RA and the findings of ∼100 additional genetic risk variants for disease susceptibility as well as several risk variants for severe disease. These findings increased our understanding of RA abnormality. Still, the mechanisms by which many of the variants exhibit their effect are not yet understood.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Artritis Reumatoide / Predisposición Genética a la Enfermedad Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Rheum Dis Clin North Am Asunto de la revista: REUMATOLOGIA Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Artritis Reumatoide / Predisposición Genética a la Enfermedad Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Rheum Dis Clin North Am Asunto de la revista: REUMATOLOGIA Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos