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Long-term outcomes of tonsillectomy for IgA nephropathy patients: A retrospective cohort study, two-centre analysis with the inverse probability therapy weighting method.
Matsumoto, Keiichiro; Ikeda, Yuki; Yamaguchi, Sae; Sanematsu, Mai; Fukuda, Makoto; Takashima, Tsuyoshi; Kishi, Tomoya; Miyazono, Motoaki; Uchiumi, Saori; Yoshizaki, Mai; Nonaka, Yasunori; Matsumoto, Ryoko; Kanaya, Akiko; Fukunari, Kenichi; Ikeda, Yuji.
Afiliación
  • Matsumoto K; Department of Internal Medicine, Saga University Faculty of Medicine, Saga, Japan.
  • Ikeda Y; Department of Internal Medicine, Saga University Faculty of Medicine, Saga, Japan.
  • Yamaguchi S; Department of Internal Medicine, Saga University Faculty of Medicine, Saga, Japan.
  • Sanematsu M; Department of Internal Medicine, Saga University Faculty of Medicine, Saga, Japan.
  • Fukuda M; Department of Internal Medicine, Saga University Faculty of Medicine, Saga, Japan.
  • Takashima T; Department of Internal Medicine, Saga University Faculty of Medicine, Saga, Japan.
  • Kishi T; Department of Internal Medicine, Saga University Faculty of Medicine, Saga, Japan.
  • Miyazono M; Department of Internal Medicine, Saga University Faculty of Medicine, Saga, Japan.
  • Uchiumi S; Department of Nephrology, Sasebo Kyosai Hospital, Nagasaki, Japan.
  • Yoshizaki M; Department of Nephrology, Sasebo Kyosai Hospital, Nagasaki, Japan.
  • Nonaka Y; Department of Nephrology, Sasebo Kyosai Hospital, Nagasaki, Japan.
  • Matsumoto R; Department of Nephrology, Sasebo Kyosai Hospital, Nagasaki, Japan.
  • Kanaya A; Department of Nephrology, Sasebo Kyosai Hospital, Nagasaki, Japan.
  • Fukunari K; Department of Nephrology, Sasebo Kyosai Hospital, Nagasaki, Japan.
  • Ikeda Y; Department of Internal Medicine, Saga University Faculty of Medicine, Saga, Japan.
Nephrology (Carlton) ; 23(9): 846-854, 2018 Sep.
Article en En | MEDLINE | ID: mdl-28703898
AIM: The effect of tonsillectomy on IgA nephropathy remains controversial. The aim of this study was to compare the effect of tonsillectomy on the outcome, end stage kidney disease (ESKD) and all-cause death in IgA nephropathy patients who did and did not undergo tonsillectomy. METHODS: All basic data were retrospectively gathered from patients who had undergone renal biopsies at two Japanese clinical centres. Two hundred and twenty-seven patients were eligible for the study, with a median age of 34 (Interquartile range (IQR): 25-43) years and median follow-up of 92 (IQR: 40-178) months. The primary endpoint was the composite outcome of the onset of ESKD and all-cause death before ESKD. We performed a Cox proportional hazard regression analysis after adjusting for patient characteristics using the inverse probability therapy weighting (IPTW) method and a Cox analysis using the Matching method. Similarly, we analyzed these outcomes in a mild cohort. RESULTS: We were unable to find any significant advantages of tonsillectomy in either analysis (IPTW and matching, HR: 0.40 (0.12-1.36) P = 0.072 and 0.78 (0.13-4.64) P = 0.786). However, in the mild cohort analysis, our data showed that the Tonsillectomy group tended to be less likely to reach the composite outcomes than the Not Tonsillectomy group with statistical significance (hazard ratio (HR), <0.001 [CI <0.001 to <0.001, P = 0.039]). CONCLUSION: In this study, our findings led us to conclude that performing tonsillectomy in an early and timely manner may have predisposition of less poor prognosis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tonsila Palatina / Tonsilectomía / Glomerulonefritis por IGA Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Nephrology (Carlton) Asunto de la revista: NEFROLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Australia
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tonsila Palatina / Tonsilectomía / Glomerulonefritis por IGA Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Nephrology (Carlton) Asunto de la revista: NEFROLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Australia