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Small molecule metalloprotease inhibitor with in vitro, ex vivo and in vivo efficacy against botulinum neurotoxin serotype A.
Jacobson, Alan R; Adler, Michael; Silvaggi, Nicholas R; Allen, Karen N; Smith, Genessa M; Fredenburg, Ross A; Stein, Ross L; Park, Jong-Beak; Feng, Xiaochuan; Shoemaker, Charles B; Deshpande, Sharad S; Goodnough, Michael C; Malizio, Carl J; Johnson, Eric A; Pellett, Sabine; Tepp, William H; Tzipori, Saul.
Afiliación
  • Jacobson AR; Absolute Science, Inc., Denver, CO, 80222, United States.
  • Adler M; Neuroscience Branch, Medical Toxicology Division, USAMRICD, APG, MD, 21010, United States. Electronic address: michael.adler2.civ@mail.mil.
  • Silvaggi NR; Department of Chemistry, Boston University, Boston, MA, 02215, United States.
  • Allen KN; Department of Chemistry, Boston University, Boston, MA, 02215, United States.
  • Smith GM; Absolute Science, Inc., Denver, CO, 80222, United States.
  • Fredenburg RA; Center for Neurologic Diseases, Brigham & Women's Hospital and Harvard Medical School, Cambridge, MA, 02139, United States.
  • Stein RL; Laboratory for Drug Discovery in Neurodegeneration, Brigham & Women's Hospital and Harvard Medical School, Cambridge, MA, 02139, United States.
  • Park JB; Division of Infectious Diseases, Tufts University Cummings School of Veterinary Medicine, North Grafton, MA, 01536, United States.
  • Feng X; Division of Infectious Diseases, Tufts University Cummings School of Veterinary Medicine, North Grafton, MA, 01536, United States.
  • Shoemaker CB; Division of Infectious Diseases, Tufts University Cummings School of Veterinary Medicine, North Grafton, MA, 01536, United States.
  • Deshpande SS; Neuroscience Branch, Medical Toxicology Division, USAMRICD, APG, MD, 21010, United States.
  • Goodnough MC; Metabiologics, Inc., Madison, WI, 53719, United States.
  • Malizio CJ; Metabiologics, Inc., Madison, WI, 53719, United States.
  • Johnson EA; Department of Bacteriology, University of Wisconsin at Madison, Madison, WI, 53706, United States.
  • Pellett S; Department of Bacteriology, University of Wisconsin at Madison, Madison, WI, 53706, United States.
  • Tepp WH; Department of Bacteriology, University of Wisconsin at Madison, Madison, WI, 53706, United States.
  • Tzipori S; Division of Infectious Diseases, Tufts University Cummings School of Veterinary Medicine, North Grafton, MA, 01536, United States.
Toxicon ; 137: 36-47, 2017 Oct.
Article en En | MEDLINE | ID: mdl-28698055
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inhibidores de Proteasas / Toxinas Botulínicas Tipo A / Metaloproteasas / Neurotoxinas Límite: Animals Idioma: En Revista: Toxicon Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inhibidores de Proteasas / Toxinas Botulínicas Tipo A / Metaloproteasas / Neurotoxinas Límite: Animals Idioma: En Revista: Toxicon Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido