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A Kinome-Wide Selective Radiolabeled TrkB/C Inhibitor for in Vitro and in Vivo Neuroimaging: Synthesis, Preclinical Evaluation, and First-in-Human.
Bernard-Gauthier, Vadim; Bailey, Justin J; Mossine, Andrew V; Lindner, Simon; Vomacka, Lena; Aliaga, Arturo; Shao, Xia; Quesada, Carole A; Sherman, Phillip; Mahringer, Anne; Kostikov, Alexey; Grand'Maison, Marilyn; Rosa-Neto, Pedro; Soucy, Jean-Paul; Thiel, Alexander; Kaplan, David R; Fricker, Gert; Wängler, Björn; Bartenstein, Peter; Schirrmacher, Ralf; Scott, Peter J H.
Afiliación
  • Bernard-Gauthier V; Department of Oncology, Division of Oncological Imaging, University of Alberta , Edmonton, Alberta T6G 2R3, Canada.
  • Bailey JJ; Department of Oncology, Division of Oncological Imaging, University of Alberta , Edmonton, Alberta T6G 2R3, Canada.
  • Mossine AV; Division of Nuclear Medicine, Department of Radiology, The University of Michigan Medical School , Ann Arbor, Michigan 48109, United States.
  • Lindner S; Department of Nuclear Medicine, Ludwig-Maximilians-University of Munich , Marchioninistrasse 15, Munich 81377, Germany.
  • Vomacka L; Department of Nuclear Medicine, Ludwig-Maximilians-University of Munich , Marchioninistrasse 15, Munich 81377, Germany.
  • Aliaga A; Translational Neuroimaging Laboratory, McGill Centre for Studies in Aging, Douglas Mental Health University Institute , 6875 Boulevard LaSalle, Montreal, Quebec H4H 1R3, Canada.
  • Shao X; Division of Nuclear Medicine, Department of Radiology, The University of Michigan Medical School , Ann Arbor, Michigan 48109, United States.
  • Quesada CA; Division of Nuclear Medicine, Department of Radiology, The University of Michigan Medical School , Ann Arbor, Michigan 48109, United States.
  • Sherman P; Division of Nuclear Medicine, Department of Radiology, The University of Michigan Medical School , Ann Arbor, Michigan 48109, United States.
  • Mahringer A; Institute of Pharmacy and Molecular Biotechnology, University of Heidelberg , Heidelberg 69120, Germany.
  • Kostikov A; McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University , 3801 University Street, Montreal, Quebec H3A 2B4, Canada.
  • Grand'Maison M; Biospective Inc. , 6100 Avenue Royalmount, Montreal, Quebec H4P 2R2, Canada.
  • Rosa-Neto P; Translational Neuroimaging Laboratory, McGill Centre for Studies in Aging, Douglas Mental Health University Institute , 6875 Boulevard LaSalle, Montreal, Quebec H4H 1R3, Canada.
  • Soucy JP; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University , 3801 University Street, Montreal, Quebec H3A 2B4, Canada.
  • Thiel A; McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University , 3801 University Street, Montreal, Quebec H3A 2B4, Canada.
  • Kaplan DR; Jewish General Hospital, Lady Davis Institute , Montreal, Quebec HT3 1E2, Canada.
  • Fricker G; Program in Neurosciences and Mental Health, Hospital for Sick Children , Toronto, Ontario M5G 0A4, Canada.
  • Wängler B; Department of Molecular Genetics, University of Toronto , Toronto, Ontario M5S1A8, Canada.
  • Bartenstein P; Institute of Pharmacy and Molecular Biotechnology, University of Heidelberg , Heidelberg 69120, Germany.
  • Schirrmacher R; Molecular Imaging and Radiochemistry, Department of Clinical Radiology and Nuclear Medicine, Medical Faculty Mannheim of Heidelberg University , Theodor-Kutzer-Ufer 1-3, Mannheim 68167, Germany.
  • Scott PJH; Department of Nuclear Medicine, Ludwig-Maximilians-University of Munich , Marchioninistrasse 15, Munich 81377, Germany.
J Med Chem ; 60(16): 6897-6910, 2017 08 24.
Article en En | MEDLINE | ID: mdl-28696690
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piridazinas / Radiofármacos / Receptor trkB / Receptor trkC / Inhibidores de Proteínas Quinasas / Imidazoles Límite: Animals / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2017 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piridazinas / Radiofármacos / Receptor trkB / Receptor trkC / Inhibidores de Proteínas Quinasas / Imidazoles Límite: Animals / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2017 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos