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Interobserver variability in target volume delineation of hepatocellular carcinoma : An analysis of the working group "Stereotactic Radiotherapy" of the German Society for Radiation Oncology (DEGRO).
Gkika, E; Tanadini-Lang, S; Kirste, S; Holzner, P A; Neeff, H P; Rischke, H C; Reese, T; Lohaus, F; Duma, M N; Dieckmann, K; Semrau, R; Stockinger, M; Imhoff, D; Kremers, N; Häfner, M F; Andratschke, N; Nestle, U; Grosu, A L; Guckenberger, M; Brunner, T B.
Afiliación
  • Gkika E; Department of Radiation Oncology, Medical Center - University of Freiburg, Robert-Koch-Str. 3, 79106, Freiburg im Breisgau, Germany. eleni.gkika@uniklinik-freiburg.de.
  • Tanadini-Lang S; Department of Radiation Oncology, University Hospital Zürich, Zurich, Switzerland.
  • Kirste S; Department of Radiation Oncology, Medical Center - University of Freiburg, Robert-Koch-Str. 3, 79106, Freiburg im Breisgau, Germany.
  • Holzner PA; Department of Visceral Surgery, Medical Center - University of Freiburg, Freiburg, Germany.
  • Neeff HP; Department of Visceral Surgery, Medical Center - University of Freiburg, Freiburg, Germany.
  • Rischke HC; Department of Radiation Oncology, Medical Center - University of Freiburg, Robert-Koch-Str. 3, 79106, Freiburg im Breisgau, Germany.
  • Reese T; Department of Nuclear Medicine, Medical Center - University of Freiburg, Freiburg, Germany.
  • Lohaus F; Department of Radiation Oncology, University Hospital Halle-Wittenberg, Halle-Wittenberg, Germany.
  • Duma MN; Department of Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
  • Dieckmann K; German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Semrau R; OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
  • Stockinger M; National Center for Tumor Diseases (NCT), Dresden, Germany.
  • Imhoff D; German Cancer Consortium (DKTK) partner site Dresden, Dresden, Germany.
  • Kremers N; Institute of Innovative Radiotherapy, Department of Radiation Sciences, Helmholtz Zentrum Munich, Munich, Germany.
  • Häfner MF; Department of Radiation Oncology, Klinikum Rechts der Isar, TU Munich, Munich, Germany.
  • Andratschke N; Department of Radiation Oncology, General Hospital Vienna, Medical University Vienna, Vienna, Austria.
  • Nestle U; Department of Radiation Oncology, University Hospital of Cologne, Cologne, Germany.
  • Grosu AL; Department of Radiation Oncology, University Hospital Mainz, Mainz, Germany.
  • Guckenberger M; Department of Radiation Oncology, University Hospital Frankfurt, Frankfurt, Germany.
  • Brunner TB; Saphir Radiosurgery Center, Frankfurt, Germany.
Strahlenther Onkol ; 193(10): 823-830, 2017 Oct.
Article en En | MEDLINE | ID: mdl-28695316
BACKGROUND: Definition of gross tumor volume (GTV) in hepatocellular carcinoma (HCC) requires dedicated imaging in multiple contrast medium phases. The aim of this study was to evaluate the interobserver agreement (IOA) in gross tumor delineation of HCC in a multicenter panel. METHODS: The analysis was performed within the "Stereotactic Radiotherapy" working group of the German Society for Radiation Oncology (DEGRO). The GTVs of three anonymized HCC cases were delineated by 16 physicians from nine centers using multiphasic CT scans. In the first case the tumor was well defined. The second patient had multifocal HCC (one conglomerate and one peripheral tumor) and was previously treated with transarterial chemoembolization (TACE). The peripheral lesion was adjacent to the previous TACE site. The last patient had an extensive HCC with a portal vein thrombosis (PVT) and an inhomogeneous liver parenchyma due to cirrhosis. The IOA was evaluated according to Landis and Koch. RESULTS: The IOA for the first case was excellent (kappa: 0.85); for the second case moderate (kappa: 0.48) for the peripheral tumor and substantial (kappa: 0.73) for the conglomerate. In the case of the peripheral tumor the inconsistency is most likely explained by the necrotic tumor cavity after TACE caudal to the viable tumor. In the last case the IOA was fair, with a kappa of 0.34, with significant heterogeneity concerning the borders of the tumor and the PVT. CONCLUSION: The IOA was very good among the cases were the tumor was well defined. In complex cases, where the tumor did not show the typical characteristics, or in cases with Lipiodol (Guerbet, Paris, France) deposits, IOA agreement was compromised.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tomografía Computarizada por Rayos X / Carcinoma Hepatocelular / Carga Tumoral / Neoplasias Hepáticas Tipo de estudio: Clinical_trials / Diagnostic_studies / Evaluation_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Strahlenther Onkol Asunto de la revista: NEOPLASIAS / RADIOTERAPIA Año: 2017 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Alemania
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tomografía Computarizada por Rayos X / Carcinoma Hepatocelular / Carga Tumoral / Neoplasias Hepáticas Tipo de estudio: Clinical_trials / Diagnostic_studies / Evaluation_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Strahlenther Onkol Asunto de la revista: NEOPLASIAS / RADIOTERAPIA Año: 2017 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Alemania