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Effects of single genetic variants and polygenic obesity risk scores on disordered eating in adolescents - The HUNT study.
Sardahaee, Farzaneh Saeedzadeh; Holmen, Turid Lingaas; Micali, Nadia; Kvaløy, Kirsti.
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  • Sardahaee FS; HUNT Research Center, Department of Public Health and Nursing, Faculty of Medicine and Health Science, Norwegian University of Science and Technology, Trondheim, Norway; Adult Psychiatry Department, Helse Nord-Trøndelag, Levanger Hospital, Levanger, Norway. Electronic address: farzaneh.sardahaee@ntn
  • Holmen TL; HUNT Research Center, Department of Public Health and Nursing, Faculty of Medicine and Health Science, Norwegian University of Science and Technology, Trondheim, Norway. Electronic address: turid.lingaas.holmen@ntnu.no.
  • Micali N; Behavioural and Brain Science Unit, UCL, London, United Kingdom; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, USA. Electronic address: n.micali@ucl.ac.uk.
  • Kvaløy K; HUNT Research Center, Department of Public Health and Nursing, Faculty of Medicine and Health Science, Norwegian University of Science and Technology, Trondheim, Norway; Department of Research and Development, Levanger Hospital, Nord-Trøndelag Health Trust, Levanger, Norway. Electronic address: kirs
Appetite ; 118: 8-16, 2017 11 01.
Article en En | MEDLINE | ID: mdl-28694222
PURPOSE: Improving the understanding of the role of genetic risk on disordered eating (DE). METHODS: A case-control study including 1757 (F: 979, M: 778) adolescents (aged 13-19 years) from the Nord-Trøndelag Health Study (HUNT), an ethnically homogenous Norwegian population based study. Cases and controls were defined using a shortened version of the Eating Attitude Test. Logistic regression was employed to test for associations between DE phenotypes and 24 obesity and eating disorder susceptibility SNPs, and the joint effect of a subset of these in a genetic risk score (GRS). RESULTS: COMT was shown to be associated with poor appetite/undereating (OR: 0.6, CI 95%: 0.43-0.83, p = 0.002). Independent of obesity associations, the weighted GRS was associated to overeating in 13-15 year old females (OR: 2.07, CI 95%: 1.14-3.76, p = 0.017). Additionally, a significant association was observed between the GRS and loss of control over eating in the total sample (OR: 1.62, CI 95%: 1.01-2.61, p = 0.046). CONCLUSIONS: The COMT variant (rs4680) was associated with poor appetite/undereating. Our study further confirms prior findings that obesity risk also confers risk for loss of control over eating; and overeating amongst girls.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Catecol O-Metiltransferasa / Trastornos de Alimentación y de la Ingestión de Alimentos / Predisposición Genética a la Enfermedad / Polimorfismo de Nucleótido Simple / Obesidad Tipo de estudio: Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Female / Humans / Male País/Región como asunto: Europa Idioma: En Revista: Appetite Año: 2017 Tipo del documento: Article Pais de publicación: Reino Unido
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Catecol O-Metiltransferasa / Trastornos de Alimentación y de la Ingestión de Alimentos / Predisposición Genética a la Enfermedad / Polimorfismo de Nucleótido Simple / Obesidad Tipo de estudio: Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Female / Humans / Male País/Región como asunto: Europa Idioma: En Revista: Appetite Año: 2017 Tipo del documento: Article Pais de publicación: Reino Unido