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Discovery of Potent and Selective Inhibitors of Cdc2-Like Kinase 1 (CLK1) as a New Class of Autophagy Inducers.
Sun, Qi-Zheng; Lin, Gui-Feng; Li, Lin-Li; Jin, Xi-Ting; Huang, Lu-Yi; Zhang, Guo; Yang, Wei; Chen, Kai; Xiang, Rong; Chen, Chong; Wei, Yu-Quan; Lu, Guang-Wen; Yang, Sheng-Yong.
Afiliación
  • Sun QZ; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy , Chengdu 610041, P.R. China.
  • Lin GF; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy , Chengdu 610041, P.R. China.
  • Li LL; Key Laboratory of Drug Targeting and Drug Delivery System of Ministry of Education, West China School of Pharmacy, Sichuan University , Sichuan 610041, P.R. China.
  • Jin XT; Key Laboratory of Drug Targeting and Drug Delivery System of Ministry of Education, West China School of Pharmacy, Sichuan University , Sichuan 610041, P.R. China.
  • Huang LY; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy , Chengdu 610041, P.R. China.
  • Zhang G; School of Chemical Engineering, Sichuan University and Collaborative Innovation Center for Biotherapy , Chengdu 610041, P.R. China.
  • Yang W; Key Laboratory of Drug Targeting and Drug Delivery System of Ministry of Education, West China School of Pharmacy, Sichuan University , Sichuan 610041, P.R. China.
  • Chen K; Key Laboratory of Drug Targeting and Drug Delivery System of Ministry of Education, West China School of Pharmacy, Sichuan University , Sichuan 610041, P.R. China.
  • Xiang R; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy , Chengdu 610041, P.R. China.
  • Chen C; Department of Clinical Medicine, School of Medicine, Nankai University , Tianjin 300071, P.R. China.
  • Wei YQ; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy , Chengdu 610041, P.R. China.
  • Lu GW; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy , Chengdu 610041, P.R. China.
  • Yang SY; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy , Chengdu 610041, P.R. China.
J Med Chem ; 60(14): 6337-6352, 2017 07 27.
Article en En | MEDLINE | ID: mdl-28692292
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Quinolinas / Autofagia / Triazoles / Proteínas Tirosina Quinasas / Proteínas Serina-Treonina Quinasas / Sustancias Protectoras / Enfermedad Hepática Inducida por Sustancias y Drogas Límite: Animals / Humans / Male Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Quinolinas / Autofagia / Triazoles / Proteínas Tirosina Quinasas / Proteínas Serina-Treonina Quinasas / Sustancias Protectoras / Enfermedad Hepática Inducida por Sustancias y Drogas Límite: Animals / Humans / Male Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos