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Chronic histiocytic intervillositis in three consecutive pregnancies in a single patient: Differing clinical results and pathology according to treatment used.
Ozawa, Nobuaki; Yamaguchi, Koushi; Shibata, Megumi; Sugibayashi, Rika; Yagi, Hiroya; Sago, Haruhiko; Matsuoka, Kentaro.
Afiliación
  • Ozawa N; Center of Maternal-Fetal, Neonatal and Reproductive Medicine, National Center for Child Health and Development, Tokyo, Japan.
  • Yamaguchi K; Center of Maternal-Fetal, Neonatal and Reproductive Medicine, National Center for Child Health and Development, Tokyo, Japan.
  • Shibata M; Center of Maternal-Fetal, Neonatal and Reproductive Medicine, National Center for Child Health and Development, Tokyo, Japan.
  • Sugibayashi R; Center of Maternal-Fetal, Neonatal and Reproductive Medicine, National Center for Child Health and Development, Tokyo, Japan.
  • Yagi H; Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.
  • Sago H; Center of Maternal-Fetal, Neonatal and Reproductive Medicine, National Center for Child Health and Development, Tokyo, Japan.
  • Matsuoka K; Department of Pathology, Dokkyo Medical University, Koshigaya Hospital, Saitama, Japan.
J Obstet Gynaecol Res ; 43(9): 1504-1508, 2017 Sep.
Article en En | MEDLINE | ID: mdl-28691359
Chronic histiocytic intervillositis (CHI) is an extremely rare pathological condition but is strongly associated with severe obstetric complications and has a high recurrence rate. The management of this condition has not yet been established. We describe herein the occurrence of CHI in the late second-third trimester in each of three consecutive pregnancies in a single patient with four previous consecutive early miscarriages. In this patient, each of the three complicated pregnancies was managed with one of the following, respectively: low-dose aspirin; heparin plus low-dose aspirin; and prednisolone plus low-dose aspirin. CHI was histologically confirmed in all three pregnancies, but the clinical results and pathology (e.g. extent of histiocytic infiltration) in each pregnancy clearly differed with treatment. Both combination treatments eventuated in a live birth. Immunosuppressive therapy seemed to produce better clinical results by restricting the extent of the affected areas. The elevated alkaline phosphatase associated with the CHI was assumed to have no clinical prognostic value.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Placentarias / Histiocitosis / Vellosidades Coriónicas Tipo de estudio: Prognostic_studies Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: J Obstet Gynaecol Res Asunto de la revista: GINECOLOGIA / OBSTETRICIA Año: 2017 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Australia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Placentarias / Histiocitosis / Vellosidades Coriónicas Tipo de estudio: Prognostic_studies Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: J Obstet Gynaecol Res Asunto de la revista: GINECOLOGIA / OBSTETRICIA Año: 2017 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Australia