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The effects of historical fragmentation on major histocompatibility complex class II ß and microsatellite variation in the Aegean island reptile, Podarcis erhardii.
Santonastaso, Trent; Lighten, Jackie; van Oosterhout, Cock; Jones, Kenneth L; Foufopoulos, Johannes; Anthony, Nicola M.
Afiliación
  • Santonastaso T; Department of Biological Sciences University of New Orleans New Orleans LA USA.
  • Lighten J; School of Environmental Sciences University of East Anglia Norwich Research Park Norwich UK.
  • van Oosterhout C; School of Environmental Sciences University of East Anglia Norwich Research Park Norwich UK.
  • Jones KL; Department of Biochemistry and Molecular Genetics University of Colorado Denver School of Medicine Denver CO USA.
  • Foufopoulos J; School of the Environment and Sustainability University of Michigan Ann Arbor MI USA.
  • Anthony NM; Department of Biological Sciences University of New Orleans New Orleans LA USA.
Ecol Evol ; 7(13): 4568-4581, 2017 07.
Article en En | MEDLINE | ID: mdl-28690787
The major histocompatibility complex (MHC) plays a key role in disease resistance and is the most polymorphic gene region in vertebrates. Although habitat fragmentation is predicted to lead to a loss in MHC variation through drift, the impact of other evolutionary forces may counter this effect. Here we assess the impact of selection, drift, migration, and recombination on MHC class II and microsatellite variability in 14 island populations of the Aegean wall lizard Podarcis erhardii. Lizards were sampled from islands within the Cyclades (Greece) formed by rising sea levels as the last glacial maximum approximately 20,000 before present. Bathymetric data were used to determine the area and age of each island, allowing us to infer the corresponding magnitude and timing of genetic bottlenecks associated with island formation. Both MHC and microsatellite variation were positively associated with island area, supporting the hypothesis that drift governs neutral and adaptive variation in this system. However, MHC but not microsatellite variability declined significantly with island age. This discrepancy is likely due to the fact that microsatellites attain mutation-drift equilibrium more rapidly than MHC. Although we detected signals of balancing selection, recombination and migration, the effects of these evolutionary processes appeared negligible relative to drift. This study demonstrates how land bridge islands can provide novel insights into the impact of historical fragmentation on genetic diversity as well as help disentangle the effects of different evolutionary forces on neutral and adaptive diversity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Ecol Evol Año: 2017 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Ecol Evol Año: 2017 Tipo del documento: Article Pais de publicación: Reino Unido