Regulation and functions of inflammasome-mediated cytokines in Helicobacter pylori infection.

Tran, Le Son; Chonwerawong, Michelle; Ferrero, Richard L

Tran, Le Son; Chonwerawong, Michelle; Ferrero, Richard L.

Afiliación

Tran LS; Centre for Innate Immunity and Infectious Diseases, The Hudson Institute of Medical Research, Monash University, 27-31 Wright Street, Clayton, Victoria, Australia.
Chonwerawong M; Centre for Innate Immunity and Infectious Diseases, The Hudson Institute of Medical Research, Monash University, 27-31 Wright Street, Clayton, Victoria, Australia.
Ferrero RL; Centre for Innate Immunity and Infectious Diseases, The Hudson Institute of Medical Research, Monash University, 27-31 Wright Street, Clayton, Victoria, Australia; Biomedicine Discovery Institute, Department of Microbiology, Monash University, Wellington Road, Clayton, Victoria, Australia. Electronic address: Richard.Ferrero@Hudson.org.au.

Microbes Infect ; 19(9-10): 449-458, 2017.

Article en En | MEDLINE | ID: mdl-28690082

RESUMEN

Persistent stomach infection with Helicobacter pylori causes chronic mucosal inflammation (gastritis), which is widely recognized as an essential precursor to gastric cancer. The IL-1 interleukin family cytokines IL-1ß and IL-18 have emerged as central mediators of mucosal inflammation. Here, we review the regulation and functions of these cytokines in H. pylori-induced inflammation and carcinogenesis.

Asunto(s)

Citocinas/metabolismo; Infecciones por Helicobacter/metabolismo; Inflamasomas/metabolismo; Citocinas/genética; Regulación de la Expresión Génica/fisiología; Infecciones por Helicobacter/inmunología; Helicobacter pylori; Humanos; Neoplasias Gástricas/etiología

Palabras clave

Gastric cancer; Helicobacter pylori; IL-18; IL-1ß; Inflammasome; NOD-like receptors

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Citocinas / Infecciones por Helicobacter / Inflamasomas Tipo de estudio: Etiology_studies Límite: Humans Idioma: En Revista: Microbes Infect Asunto de la revista: ALERGIA E IMUNOLOGIA / MICROBIOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Francia

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