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Neonatal abstinence syndrome and early childhood morbidity and mortality in Washington state: a retrospective cohort study.
Witt, C E; Rudd, K E; Bhatraju, P; Rivara, F P; Hawes, S E; Weiss, N S.
Afiliación
  • Witt CE; Department of Epidemiology, University of Washington, Seattle, WA, USA.
  • Rudd KE; Harborview Injury Prevention and Research Center, Seattle, WA, USA.
  • Bhatraju P; Department of Surgery, University of Washington, Seattle, WA, USA.
  • Rivara FP; Department of Epidemiology, University of Washington, Seattle, WA, USA.
  • Hawes SE; Division of Pulmonary and Critical Care Medicine, University of Washington, Seattle, WA, USA.
  • Weiss NS; Department of Epidemiology, University of Washington, Seattle, WA, USA.
J Perinatol ; 37(10): 1124-1129, 2017 10.
Article en En | MEDLINE | ID: mdl-28682319
OBJECTIVE: The objective of the study was to evaluate the association between neonatal abstinence syndrome (NAS) and long-term childhood morbidity and infant mortality. STUDY DESIGN: We conducted a cohort study of infants born in Washington State during 1990 to 2008 who were diagnosed with NAS (n=1900) or were unexposed (n=12,283, frequency matched by birth year). 5-year hospital readmissions and infant mortality were ascertained. RESULTS: Children with history of NAS had increased risk of readmission during the first 5 years of life relative to unexposed children; this remained statistically significant after adjustment for maternal age, maternal education, gestational age and intrapartum smoking status (readmission rates: NAS=21.3%, unexposed=12.7%, adjusted relative risk (aRR) 1.54, 95% confidence interval (CI) 1.37 to 1.73). NAS was associated with increased unadjusted infant mortality risk, but this did not persist after adjustment (aRR 1.94, 95% CI 0.99 to 3.80). CONCLUSION: The observed increased risk for childhood hospital readmission following NAS diagnosis argues for development of early childhood interventions to prevent morbidity.Journal of Perinatology advance online publication,.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Readmisión del Paciente / Síndrome de Abstinencia Neonatal Tipo de estudio: Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adult / Child, preschool / Female / Humans / Infant / Male / Newborn / Pregnancy País/Región como asunto: America do norte Idioma: En Revista: J Perinatol Asunto de la revista: PERINATOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Readmisión del Paciente / Síndrome de Abstinencia Neonatal Tipo de estudio: Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adult / Child, preschool / Female / Humans / Infant / Male / Newborn / Pregnancy País/Región como asunto: America do norte Idioma: En Revista: J Perinatol Asunto de la revista: PERINATOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos