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MicroRNA-133b expression associates with clinicopathological features and prognosis in glioma.
Xue, Kun; Yang, Junmei; Hu, Jia; Liu, Jianhui; Li, Xingang.
Afiliación
  • Xue K; a Department of Neurosurgery , Qilu Hospital of Shandong University , Jinan , Shandong , China.
  • Yang J; b Department of Neurosurgery , Yantaishan Hospital , Yantai , Shandong , China.
  • Hu J; c Second Traumatic orthopedics , Yantaishan Hospital , Yantai , Shandong , China.
  • Liu J; b Department of Neurosurgery , Yantaishan Hospital , Yantai , Shandong , China.
  • Li X; b Department of Neurosurgery , Yantaishan Hospital , Yantai , Shandong , China.
Artif Cells Nanomed Biotechnol ; 46(4): 815-818, 2018 Jun.
Article en En | MEDLINE | ID: mdl-28675056
BACKGROUND: Recently, microRNA-133b (miR-133b) dysregulation has been shown to play a key role in several human cancers, as well as glioma. In this study, we aimed to investigate the clinical significance and prognostic value of miR-133b in glioma. METHODS: Real-time quantitative PCR was employed to measure the expression level of miR-133b in tissues. Survival analysis was carried out by using the log-rank test and Kaplan-Meier method. Prognostic factors for overall survival were identified by univariate and multivariate analyses using the Cox proportional hazards regression model. RESULTS: The expression level of miR-133b was significantly lower in glioma tissues compared with matched non-cancerous brain tissues (p < .05). Its level was strongly correlated with Karnofsky Performance Scale score (p < .001) and WHO grade (p < .001). Kaplan-Meier survival and log-rank analysis indicated that the decreased expression of miR-133b was strongly correlated with shorter overall survival of patients with glioma (log-rank test, p = .03). CONCLUSIONS: The current investigation demonstrated that miR-133b level is useful for predicting the prognosis of patients with glioma.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ARN Neoplásico / Regulación Neoplásica de la Expresión Génica / MicroARNs / Glioma Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Artif Cells Nanomed Biotechnol Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ARN Neoplásico / Regulación Neoplásica de la Expresión Génica / MicroARNs / Glioma Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Artif Cells Nanomed Biotechnol Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido